Gene interactions and pathways from curated databases and text-mining

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AFP — HGF

Text-mined interactions from Literome

Iseki et al., Int J Oncol 2000 (Carcinoma, Hepatocellular) : By the transfection assay, HGF stimulated albumin promoter activity but repressed alpha-fetoprotein (AFP) enhancer activity regulating both AFP and albumin promoters in HepG2 cells
Hatano et al., Biochem Biophys Res Commun 1992 (Carcinoma, Hepatocellular...) : In the present study, the effect of HGF on the alpha-fetoprotein (AFP) gene expression was analyzed in PLC/PRF/5 human hepatoma cells ... HGF did not inhibit cell proliferation, but dose-dependently suppressed AFP secretion at the concentrations of 10 ng/ml or less ... In the transient chloramphenicol acetyltransferase plasmid transfection assays, the AFP promoter activity was repressed by HGF , in contrast, the AFP enhancer activity was not affected by HGF ... These results suggest that the AFP gene expression is down-regulated by HGF through the suppression of its promoter activity in human hepatoma cells
Ma et al., Zhonghua Gan Zang Bing Za Zhi 2004 : The rat hepatic injury serum or HGF could stimulate the expression of AFP protein and it 's mRNA of bone marrow cells