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AFP — HGF
Text-mined interactions from Literome
Iseki et al., Int J Oncol 2000
(Carcinoma, Hepatocellular) :
By the transfection assay,
HGF stimulated albumin promoter activity but
repressed alpha-fetoprotein (AFP) enhancer activity regulating both AFP and albumin promoters in HepG2 cells
Hatano et al., Biochem Biophys Res Commun 1992
(Carcinoma, Hepatocellular...) :
In the present study, the
effect of
HGF on the
alpha-fetoprotein (AFP) gene expression was analyzed in PLC/PRF/5 human hepatoma cells ...
HGF did not inhibit cell proliferation, but dose-dependently
suppressed AFP secretion at the concentrations of 10 ng/ml or less ... In the transient chloramphenicol acetyltransferase plasmid transfection assays, the
AFP promoter activity was
repressed by
HGF , in contrast, the AFP enhancer activity was not affected by HGF ... These results suggest that the
AFP gene expression is
down-regulated by
HGF through the suppression of its promoter activity in human hepatoma cells
Ma et al., Zhonghua Gan Zang Bing Za Zhi 2004
:
The rat hepatic injury serum or
HGF could
stimulate the expression of
AFP protein and it 's mRNA of bone marrow cells