Cui et al., Mol Endocrinol 2002
:
We demonstrated that insulin mediated insulin receptor substrate (IRS)-2 associated PI3K activity was inhibited by AT2 receptor stimulation, whereas IRS-1 associated PI3K activity was not significantly influenced
Senbonmatsu et al., EMBO J 2003
(Cardiomegaly) :
AT(2) enhances expression of p85 alpha PI3K followed by enhanced p70 ( S6 ) kinase, essential to protein synthesis