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AHSA1 — MMP13
Text-mined interactions from Literome
Loeser et al., J Biol Chem 2003
:
FN-f stimulated
MMP-13 promoter activity was also
inhibited by chemical inhibitors of ERK, JNK, and
p38 mitogen activated protein ( MAP ) kinases or by co-transfection of dominant negative MAP kinase mutant constructs
Lee et al., J Biomed Sci 2003
(Liver Cirrhosis) :
Differential
role of
p38 in IL-1alpha induction of MMP-9 and
MMP-13 in an established liver myofibroblast cell line
Kimura et al., J Pharmacol Sci 2009
(Osteoarthritis) :
An ERK-MAPK pathway inhibitor ( U0126 ), but not a
p38 kinase inhibitor ( SB203580 ) or a JNK inhibitor ( SP600125 ), also selectively
inhibited IL-1beta induced
MMP-13 production in HAC
Ravanti et al., J Biol Chem 1999
:
These results show that collagen dependent induction of
MMP-13 in dermal fibroblasts
requires p38 activity, and is inhibited by activation of ERK1,2