Gene interactions and pathways from curated databases and text-mining

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AHSA1 — SERPINE1

Text-mined interactions from Literome

Hsieh et al., J Rheumatol 2007 (Osteoarthritis, Knee) : Enzyme linked immunosorbent assay and gelatin zymography were used to investigate the effects of ERK 1/2 inhibitor U0126, JNK and p38 inhibitor SB203580, and PI3K inhibitor LY294002 on the secretion of u-PA, PAI-1 , MMP-2, and MMP-9 in early osteoarthritic tissue cultures, with or without interleukin 1alpha (IL-1alpha) and lipopolysaccharide (LPS) induction
Wu et al., Circ J 2012 : The stimulation of PAI-1 by GlcN alone or by GlcN and TNF-a in combination was inhibited by the specific inhibitor of p38mapk , but not that of JNK or ERK1/2