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AKT1 — RPL17

Text-mined interactions from Literome

Parry et al., Mol Cell Biol 2005 : Ligation of both CTLA-4 and PD-1 blocked CD3/CD28 mediated upregulation of glucose metabolism and Akt activity, but each accomplished this regulation using separate mechanisms ... In contrast, PD-1 signaling inhibits Akt phosphorylation by preventing CD28 mediated activation of phosphatidylinositol 3-kinase (PI3K)
Chen et al., Transpl Int 2008 (Disease Models, Animal) : In vitro, PD-1-Tg T cells had reduced proliferative and cytokine secretion capacity upon TCR stimulation and cross linking of PD-1 resulted in diminished phosphorylation of protein kinase C-theta and Akt , as well as increased activation of the phosphate and tensin homolog
Patsoukis et al., Cell cycle (Georgetown, Tex.) 2012 : The suppressive effect of PD-1 on Skp2 expression was mediated by inhibition of both PI3K/Akt and Ras/MEK/Erk pathways and was only partially reversed by IL-2, which restored activation of MEK/Erk but not Akt