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AKT3 — CDK2

Text-mined interactions from Literome

Maddika et al., J Cell Sci 2008 : Akt mediated phosphorylation of CDK2 regulates its dual role in cell cycle progression and apoptosis ... Here, we show that CDK2 , an S-phase cyclin dependent kinase, is a novel target for Akt during cell cycle progression and apoptosis ... Although CDK2 threonine 39 phosphorylation mediated by Akt enhances cyclin-A binding, it is dispensable for its basal binding and the kinase activity
Yin et al., Prostate 2009 (Prostatic Neoplasms) : In prostate cancer C/EBPalpha promotes cell growth by the loss of interactions with CDK2 , CDK4, and E2F and by activation of AKT
Villavicencio et al., Gynecol Oncol 2009 (Endometrial Hyperplasia...) : The PCOS condition is associated with increased Ser473-AKT phosphorylation, elevated expression of Ras, increased cytoplasmic abundance of p27, and increased nuclear abundance of CDK2 in the endometrial epithelial cells