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AKT3 — PARP1

Text-mined interactions from Literome

Tsygankova et al., Mol Cell Biol 2001 : The ability of TSH to stimulate Akt phosphorylation was markedly enhanced by the expression of activated Rap1A and was repressed in cells expressing a putative dominant negative Rap1A mutant ... Although the expression of activated Rap1A was sufficient to stimulate wortmannin-sensitive Akt phosphorylation, TSH further increased Akt phosphorylation in a phosphatidylinositol 3-kinase- and PKA dependent manner
Wang et al., J Biol Chem 2001 : Moreover, inhibition of Rap1 by a Rap1 GTPase activating protein-1 also resulted in a decrease in ERK and Akt phosphorylation, which was not further decreased by cAMP, suggesting that cAMP inhibits ERK and Akt by inhibiting Rap1 ... The role of Rap1 in ERK and Akt activity was further demonstrated by our observation that an active form of Epac, which activated Rap1 in the absence of cAMP, increased ERK and Akt phosphorylation
Tapodi et al., J Biol Chem 2005 (Necrosis) : These data together with the finding that PARP inhibition in the absence of oxidative stress induced the phosphorylation and activation of Akt indicate that PARP inhibition induced Akt activation is dominantly responsible for the cytoprotection in oxidative stress
Romano et al., Endocrinology 2006 : Under the same conditions, PI3K and Akt inhibition also both increased Raf-1 kinase activity and the levels of GTP bound ( active form ) monomeric G protein Rap1 , which suggests that a down-regulation of the ERK-1/2 cascade is induced by the PI3K/Akt signaling pathway in unstimulated cells
Mathews et al., Arterioscler Thromb Vasc Biol 2008 : PARP-1 inhibition can also activate the prosurvival serine/threonine kinase, Akt ... PARP-1 inhibition increased Akt , BAD, and VEGFR2 phosphorylation in HUVECs and in PJ34 treated rabbit aortas
Pacurari et al., Environ Health Perspect 2008 (Neoplasms, Mesothelial) : In the present study, we exposed mesothelial cells to SWCNTs and investigated reactive oxygen species ( ROS ) generation, cell viability, DNA damage, histone H2AX phosphorylation, activation of poly(ADP-ribose) polymerase 1 ( PARP-1 ), stimulation of extracellular signal regulated kinase ( ERKs ), Jun N-terminal kinases (JNKs), protein p38, and activation of activator protein-1 (AP-1), nuclear factor kappaB (NF-kappaB), and protein serine-threonine kinase ( Akt )
Szanto et al., Biochem Pharmacol 2009 : To understand the role of Akt activation in the combined use of cytostatic agent and PARP inhibition, we used taxol ( paclitaxel ) as an antineoplastic agent, which targets microtubules and up-regulates mitochondrial ROS production, together with ( i ) pharmacological inhibition ( PJ-34 ), ( ii ) siRNA knock-down and ( iii ) transdominant expression of the DNA binding domain of PARP-1
Edreira et al., J Biol Chem 2009 : cAMP dependent protein kinase (PKA) mediated phosphorylation of Rap1b is required for cAMP dependent mitogenesis, tumorigenesis, and inhibition of AKT activity
Gatson et al., Journal of neuroinflammation 2009 (Burns...) : In addition, we determined that in the estrogen treated rats there was an increase in the levels of phospho-ERK ( p < 0.01 ) and Akt ( p < 0.05 ) at the 24 hour time-point, and that 17 beta-estradiol blocked the activation of caspase-3 ( p < 0.01 ) and subsequent cleavage of PARP ( p < 0.05 )
Malchinkhuu et al., Mol Biol Cell 2009 (Glioma) : The expression of tumor suppressor phosphatase and tensin homolog deleted on chromosome 10 ( PTEN ) is required for the inhibitory ISO induced and Rap1B mediated actions on the migration, Rac1 activation, and Akt activation in response to LPA
Mallon et al., Mol Cancer Ther 2010 : We are testing whether dual PI3K/mTOR inhibitors can durably suppress p-Akt , induce cleaved PARP , and cause tumor regression in a diverse set of human tumor xenograft models
Tawa et al., Circ Res 2010 (Disease Models, Animal...) : Rap1 regulated the interaction between afadin and phosphatidylinositol 3-kinase (PI3K), recruitment of the afadin-PI3K complex to the leading edge, and the activation of Akt , indicating the involvement of Rap1 and afadin in the PI3K-Akt signaling pathway
Wang et al., Biochem Biophys Res Commun 2011 : PARP1 inhibitors attenuate AKT phosphorylation via the upregulation of PHLPP1