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ALOX5 — PTGS2

Text-mined interactions from Literome

Ye et al., J Pharmacol Exp Ther 2004 (Colonic Neoplasms) : However, 5-lipoxygenase inhibition had no effect on alpha7-nAChR mRNA expression, but significantly inhibited cell proliferation and activation of NF-kappaB and cyclooxygenase-2 , whereas NF-kappaB-specific inhibitor caffeic acid phenethyl ester reduced both cell proliferation and cyclooxygenase expression induced by NNK without affecting alpha7-nAChR mRNA level and 5-lipoxygenase expression
Ghosh et al., Am J Physiol Heart Circ Physiol 2007 (Myocarditis) : The low PUFA diet ( % energy, 1.2 % LA+0.06 % ALA ) increased arachidonic acid ( AA ) and decreased eicosapentaenoic acid ( EPA ) in heart membranes and increased Ca ( 2+ ) -independent iPLA ( 2 ) activity, COX-2 expression, and activation of 5-LO
Horrillo et al., J Pharmacol Exp Ther 2007 (Drug-Induced Liver Injury...) : Separate administration of 4-[5- ( 4-chlorophenyl ) -3- ( trifluoromethyl ) -1H-pyrazol-1-yl ] benzenesulfonamide ( SC-236 ), a selective COX-2 inhibitor, and CJ-13,610, a 5-LO inhibitor , to carbon tetrachloride treated mice significantly reduced fibrosis as revealed by the analysis of Sirius Red stained liver sections without affecting necroinflammation
Manigrasso et al., Acta Orthop 2010 (Femoral Fractures) : We hypothesized that 5-LO is a negative regulator of fracture healing and that in the absence of COX-2 , excess leukotrienes synthesized by 5-LO will impair fracture healing
Lesch et al., J Pharmacol Exp Ther 1998 (Stomach Ulcer) : Derivatives of 2,6-di-tert-butylphenol, whose members may act as PGHS-1/PGHS-2 inhibitors, selective PGHS-2 inhibitors or PGHS/5-LO dual inhibitors , are novel anti-inflammatory compounds that are devoid of GI irritating effects and do not affect the rate of pre existing gastric ulcer healing