Gene interactions and pathways from curated databases and text-mining

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ANG — PIK3R1

Text-mined interactions from Literome

Yano et al., J Biol Chem 2007 : ANG II induced a significant increase in PI3K activity, which was abolished by co-treatment with losartan or 2',5'-dideoxyadenosine ( 2',5'-DOA, an adenylyl cyclase inhibitor ) but not by PD123319 ( an AT-2R antagonist ) or H89 ( a protein kinase A (PKA) inhibitor )
Giani et al., Am J Physiol Heart Circ Physiol 2007 : The specific JAK2 inhibitor AG-490 blocked ANG- ( 1-7 ) -induced JAK2 and IRS-1 phosphorylation but had no effect on ANG- ( 1-7 ) -induced phosphorylation of Akt, indicating that activation of cardiac Akt by ANG- ( 1-7 ) appears not to involve the recruitment of JAK2 but proceeds through the receptor Mas and involves PI3K