Gene interactions and pathways from curated databases and text-mining

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ANPEP — TNF

Text-mined interactions from Literome

Kido et al., Clin Exp Metastasis 1999 (Bone Neoplasms...) : TNF-alpha and TGF-beta, however, had an effect neither on mRNA expression nor on the enzyme activity of APN in both cell lines
Hatanaka et al., Inflammation 2002 : Up-regulation of CD13/aminopeptidase N induced by phorbol ester is involved in redox regulation and tumor necrosis factor alpha production in HL-60 cells
Uji et al., J Surg Res 2010 (Disease Models, Animal...) : APN deficiency resulted in significant increases in the plasma levels of TNF-alpha , IL-6, and MCP-1 at 24 h after CLP
Higuchi et al., Arterioscler Thromb Vasc Biol 2010 (Diabetic Retinopathy...) : These data show that TZDs attenuate pathological retinal microvessel formation through APN mediated modulation of TNF-alpha production