Gene interactions and pathways from curated databases and text-mining

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ANXA6 — MAPK14

Text-mined interactions from Literome

Majidi et al., J Biol Chem 2000 : Furthermore, expression of p70 in COS-7 cells suppresses activation of mitogen activated protein kinase MAPK/ERK2 by the largest ST5 product, p126, in response to epidermal growth factor stimulation
Conejo et al., J Cell Physiol 2001 (MAP Kinase Signaling System) : This mitogenic effect of insulin was precluded by inhibition of p70S6-kinase ( either by rapamycin or by the PI3-kinase inhibitor LY294002 ) as well as by inhibition of p44/p42-MAPK with PD098059, but was not affected by inhibition of p38-MAPK
Patel et al., Diabetes 2003 : None of the inhibitors significantly inhibited protein content over 20 days, but lipid content and lipogenic activity were inhibited by p70 ( S6 ) kinase and p38 MAPK inhibition but not by p42/44 MAPK or PI3K inhibition
Le Pabic et al., J Hepatol 2005 : The phophatidylinositol 3-kinase (PI3K) inhibitor LY294002 and the mitogen activated protein kinase inhibitor, UO126, decreased the TGF-beta1 dependent ADAM12 expression and prevented the phosphorylation of p70S6K
Brereton et al., J Immunol 2009 (Autoimmune Diseases) : In this study, we show that inhibition of ERK MAPK suppressed IL-23 and IL-1beta production by dendritic cells stimulated with TLR or dectin-1 agonists but did not affect IL-12p70 production
Mitchell et al., J Infect Dis 2010 : IL-12p40 was significantly inhibited by both p38 mitogen activated protein kinase ( MAPK ) and extracellular signal regulated kinase inhibitors, whereas IL-12p70 was inhibited by p38 MAPK inhibitor alone
Yeh et al., Differentiation 2012 : Immunoblot analysis revealed early ( 1h ) activation of the mitogen activated protein kinase ( MAPK) ERK1/2, and progressive activation of epidermal growth factor receptor (EGFR), p38MAPK and p70S6 kinase (p70S6K) during 72h of isoproterenol treatment
Peart et al., Rejuvenation Res 2012 (Ischemia...) : In summary, moderate age worsens cardiac ischemic tolerance ; this is associated with reduced expression of autophagy regulators, dysregulation of p70S6K and GSK3ß, and postischemic p38-MAPK activation
Giasson et al., J Biol Chem 1995 : The immunosuppressant drug rapamycin was found to selectively inhibit the activation of p70S6K by AII, but not the activation of mitogen activated protein kinase or the induction of c-fos mRNA expression
Baxter et al., Eur J Biochem 1995 : However, the activation of p70S6K by PDGF ( or nerve growth factor ), but not the activation of mitogen-activated-protein kinase , was prevented by two structurally unrelated inhibitors of inositol phospholipid 3-kinase, wortmannin or LY294002
Sharma et al., Mol Cell Biol 1997 : In both cell types, overexpression of either the PTB or the SAIN protein caused a significant decrease in insulin induced tyrosine phosphorylation of IRS-1 and Shc proteins, IRS-1 associated phosphatidylinositol 3-kinase (PI 3-K) enzymatic activity, p70s6k activation , and p44 and p42 mitogen activated protein kinase ( MAPK ) phosphorylation
Majidi et al., J Biol Chem 1998 : In vivo, expression of p126, but not p82 or p70 , activated MAPK/ERK2 in response to EGF in COS-7 cells