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ANXA6 — PIK3R1
Text-mined interactions from Literome
Fresno Vara et al., Mol Biol Cell 2001
:
In contrast, they inhibited the PRL dependent stimulation of the SFKs substrate Sam68, the phosphorylation of the tyrosine phosphatase Shp2, and the
PI3K dependent Akt and
p70S6k serine kinases
Gonzalez-Garcia et al., J Biol Chem 2002
:
The p85 C-terminal SH2 domain is responsible for p85 coupling to p70S6K and FRAP, because deletion of the C-terminal SH2 domain inhibits complex formation and impairs
p70S6K activation by
PI3K
Tu et al., J Pharmacol Exp Ther 2002
:
Inactivating
PI3K with wortmannin
prevented H2O2 from inducing Thr389 phosphorylation and
p70S6K1 activation
Shi et al., J Biol Chem 2002
(MAP Kinase Signaling System...) :
Because activation of the
PI3-K/AKT as well as RAS-MEK-ERK pathways may
result in downstream stimulation of the
p70 ( S6K ) ( p70 ) and phosphorylation of the 4E-BP1 translational repressor, we assessed these potential molecular targets in IL-6 treated myeloma cells
Patel et al., Diabetes 2003
:
None of the inhibitors significantly inhibited protein content over 20 days, but lipid content and lipogenic activity were inhibited by
p70 ( S6 ) kinase and p38 MAPK inhibition but not by p42/44 MAPK or
PI3K inhibition
Le et al., Oncogene 2003
:
Inhibitors of mTOR,
PI3K , and Ca ( ++ )
impair p70S6K activity, whereas inhibitors of JNK and PKC stimulate p70S6K activity
Yamada et al., Biochem J 2004
:
The
PI3K inhibitor LY294002
inhibited the ActD induced activation of Akt and
p70S6K , and completely abolished the effects of PLD1 or PLD2, whereas inhibition of ERK activity by the MEK inhibitor U0126 had a milder effect
Skinner et al., J Biol Chem 2004
(Ovarian Neoplasms) :
The inhibition of
PI3K by LY294002
inhibited p70S6K1 and HDM2 activity in the cells
Jang et al., Cell Signal 2005
:
Interestingly, there was
PI3K dependent
activation of AKT,
p70S6K , JNKs, and NF-kappaB in response to catalase
Bridle et al., J Lab Clin Med 2006
:
When evaluating potential crosstalk between these signaling pathways, we observed that
PI3-K is
required for
p70-S6-K activation by IGF-1 and PDGF, and is partially responsible for PDGF induced ERK activation
Saegusa et al., Mol Immunol 2007
:
The enhancement
effect of
PI3K inhibitors on IL-12
p70 production almost completely disappeared by the treatment with anti-IL-10 mAb ... A specific ERK inhibitor, U0126, as well as
PI3K inhibitors, differentially
regulated IL-10 and IL-12
p70 productions ... These results suggest that
PI3K positively and negatively
regulates the production of CpG-ODN induced IL-10 and IL-12
p70 , respectively, and negatively regulates IL-12 p70 production in macrophages through ERK mediated IL-10 induction
Garcia et al., J Immunol 2009
:
In the present study, we demonstrate that
IL-12p70 induces IL-10 production from human memory CD4+ T cells via a
PI3K dependent signaling mechanism
Matheny et al., Biochem Biophys Res Commun 2009
:
Our results collectively suggest that
mTOR/p70S6K is activated in a
PI3K/Akt dependent manner, but that in the absence of p110alpha or Akt, alternate pathway ( s ) may mediate activation of mTOR/p70S6K in C2C12 myoblasts
Lee et al., J Biol Chem 2010
:
OSS also induced sustained activation of ERK, which was inhibited by the specific
PI3K inhibitor LY294002 and was
required for OSS induced activation of
mTOR/p70S6K and proliferation in MG63 cells
Wenink et al., J Immunol 2009
:
The inhibitory effect of TLR2 on the release of TNF-alpha but not of
IL-12p70 was
mediated by
PI3K
Faghiri et al., Exp Eye Res 2010
:
Inhibition of
PI3K or mTOR/p70S6K by wortmannin and rapamycin, respectively, increased apoptosis and
inhibited phosphorylation of Akt and
p70S6K induced by single-dose oxidative stress
Chung et al., J Endocrinol 2013
(MAP Kinase Signaling System) :
Our data also suggest that
PI3K/Akt mediated inactivation of GSK-3ß and
activation of
mTOR/p70 ( S6K ) contribute to the proliferative effect of ghrelin
Conus et al., J Biol Chem 1998
:
Furthermore, although PI3K in anti-phosphotyrosine immunoprecipitates is only very weakly activated by ionomycin, the calcium induced stimulation of
p70 ( S6k ) is completely
inhibited by the specific
PI3K inhibitor wortmannin
Kunapuli et al., J Biol Chem 1998
(Cardiomegaly) :
However, both wortmannin, a
PI3K inhibitor, and rapamycin, an
inhibitor of
p70 ( S6K ) activity, inhibit 8,12-iso-iPF2alpha-III -induced myocyte hypertrophy, with IC50 values of 60 +/- 12 and 3 +/- 1.7 nM, respectively, whereas neither compound abrogates the PGF2alpha mediated response
Bragado et al., Gastroenterology 1998
(Diabetes Mellitus, Experimental) :
Rapamycin and
PI 3K inhibitors, wortmannin and LY294002,
blocked CCK stimulated
p70 S6K activity