◀ Back to MAPK7
APOE — MAPK7
Text-mined interactions from Literome
Ho et al., J Biol Chem 2001
(MAP Kinase Signaling System) :
Further analyses demonstrated that exogenous and endogenous
apoE prevented activation of
MAPK but not induction of c-fos expression in response to serum growth factors
Maezawa et al., Journal of neuroinflammation 2006
:
Our results suggest that LPS activation of innate immune response in TR APOE glia results in opposing outcomes from microglia and astrocytes as a
result of TR
APOE dependent activation of
p38MAPK or NF-kappaB signaling in these two cell types
Liu et al., Journal of neuroinflammation 2011
(Inflammation) :
Inhibitors of
MAPK-p38 , ERK, and JNK
inhibited ApoE induction by all these agents except glutamate, which was sensitive only to inhibitors of ERK and JNK
Kim et al., Exp Cell Res 2013
:
While ApoE did not affect the activation of ERK, JNK, and p38
MAPK signaling pathways by RANKL, the phosphorylation of p65 trans-activation domain on serine 536 and transcription activity of NF-?B were
reduced by
ApoE overexpression