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ARHGDIA — RAC1

Pathways - manually collected, often from reviews:

• NCI Pathway Database Regulation of RAC1 activity: RAC1/GDP complex (RAC1) → RHOGDI (ARHGDIA) (modification, collaborate) Sasaki et al., J Biol Chem 1993*, Hancock et al., EMBO J 1993*
  Evidence: assay
• NCI Pathway Database Regulation of RAC1 activity: RAC1/GDP complex (RAC1) → RAC1/GDP/RHOGDI complex (ARHGDIA-RAC1) (modification, collaborate)
  Sasaki et al., J Biol Chem 1993*, Hancock et al., EMBO J 1993*
  Evidence: assay
• NCI Pathway Database Regulation of RAC1 activity: RHOGDI (ARHGDIA) → RAC1/GDP/RHOGDI complex (ARHGDIA-RAC1) (modification, collaborate)
  Sasaki et al., J Biol Chem 1993*, Hancock et al., EMBO J 1993*
  Evidence: assay
• NCI Pathway Database Regulation of RAC1 activity: RAC1/GDP complex (RAC1) → RHOGDI (ARHGDIA) (modification, collaborate) Hart et al., J Biol Chem 1994, Yaku et al., Biochem Biophys Res Commun 1994*
  Evidence: assay, physical interaction
• NCI Pathway Database RAC1 signaling pathway: RHOGDI (ARHGDIA) → RAC1/GDP complex (RAC1) (modification, collaborate) DerMardirossian et al., Mol Cell 2004*
  Evidence: assay
• NCI Pathway Database RAC1 signaling pathway: RHOGDI (ARHGDIA) → RAC1/GDP/RHOGDI complex (ARHGDIA-RAC1) (modification, collaborate)
  DerMardirossian et al., Mol Cell 2004*
  Evidence: assay
• NCI Pathway Database RAC1 signaling pathway: RAC1/GDP complex (RAC1) → RAC1/GDP/RHOGDI complex (ARHGDIA-RAC1) (modification, collaborate)
  DerMardirossian et al., Mol Cell 2004*
  Evidence: assay
• NCI Pathway Database RAC1 signaling pathway: PAK1 (PAK1) → RAC1/GDP/RHOGDI complex (ARHGDIA-RAC1) (modification, activates)
  DerMardirossian et al., Mol Cell 2004*
  Evidence: assay
• NCI Pathway Database PDGFR-beta signaling pathway: RHOGDI (ARHGDIA) → RAC1/GDP complex (RAC1) (modification, collaborate) DerMardirossian et al., Mol Cell 2004*
  Evidence: assay
• NCI Pathway Database PDGFR-beta signaling pathway: RHOGDI (ARHGDIA) → RAC1/GDP/RHOGDI complex (ARHGDIA-RAC1) (modification, collaborate)
  DerMardirossian et al., Mol Cell 2004*
  Evidence: assay
• NCI Pathway Database PDGFR-beta signaling pathway: RAC1/GDP complex (RAC1) → RAC1/GDP/RHOGDI complex (ARHGDIA-RAC1) (modification, collaborate)
  DerMardirossian et al., Mol Cell 2004*
  Evidence: assay
• NCI Pathway Database PDGFR-beta signaling pathway: PAK1 (PAK1) → RAC1/GDP/RHOGDI complex (ARHGDIA-RAC1) (modification, activates)
  DerMardirossian et al., Mol Cell 2004*
  Evidence: assay
• NCI Pathway Database Regulation of RAC1 activity: RHOGDI (ARHGDIA) → RAC1/GTP complex (RAC1) (modification, collaborate) Chuang et al., J Biol Chem 1993*, Hancock et al., EMBO J 1993*
  Evidence: assay, physical interaction
• NCI Pathway Database Regulation of RAC1 activity: RHOGDI (ARHGDIA) → RAC1/GTP/RHOGDI complex (RAC1-ARHGDIA) (modification, collaborate)
  Chuang et al., J Biol Chem 1993*, Hancock et al., EMBO J 1993*
  Evidence: assay, physical interaction
• NCI Pathway Database Regulation of RAC1 activity: RAC1/GTP complex (RAC1) → RAC1/GTP/RHOGDI complex (RAC1-ARHGDIA) (modification, collaborate)
  Chuang et al., J Biol Chem 1993*, Hancock et al., EMBO J 1993*
  Evidence: assay, physical interaction
• NCI Pathway Database CDC42 signaling events: RHOGDI (ARHGDIA) → RAC1/GDP complex (RAC1) (modification, collaborate) DerMardirossian et al., Mol Cell 2004*
  Evidence: mutant phenotype, assay
• NCI Pathway Database CDC42 signaling events: RHOGDI (ARHGDIA) → RAC1/GDP/RHOGDI complex (ARHGDIA-RAC1) (modification, collaborate)
  DerMardirossian et al., Mol Cell 2004*
  Evidence: mutant phenotype, assay
• NCI Pathway Database CDC42 signaling events: RAC1/GDP complex (RAC1) → RAC1/GDP/RHOGDI complex (ARHGDIA-RAC1) (modification, collaborate)
  DerMardirossian et al., Mol Cell 2004*
  Evidence: mutant phenotype, assay
• NCI Pathway Database CDC42 signaling events: PAK1 (PAK1) → RAC1/GDP/RHOGDI complex (ARHGDIA-RAC1) (modification, activates)
  DerMardirossian et al., Mol Cell 2004*
  Evidence: mutant phenotype, assay

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

• IRef Biogrid Interaction: ARHGDIA — RAC1 (physical association, affinity chromatography technology) Yu et al., J Biol Chem 2012*
• IRef Biogrid Interaction: ARHGDIA — RAC1 (direct interaction, two hybrid) Vinayagam et al., Science signaling 2011
• IRef Biogrid Interaction: ARHGDIA — RAC1 (physical association, affinity chromatography technology) Ewing et al., Molecular systems biology 2007
• IRef Biogrid Interaction: ARHGDIA — RAC1 (association, x-ray crystallography) Lian et al., Structure 2000*
• IRef Biogrid Interaction: ARHGDIA — RAC1 (direct interaction, pull down) Grizot et al., Biochemistry 2001*
• IRef Biogrid Interaction: ARHGDIA — RAC1 (association, x-ray crystallography) Grizot et al., Biochemistry 2001*
• IRef Biogrid Interaction: ARHGDIA — RAC1 (association, biochemical) Gorvel et al., FEBS Lett 1998*
• IRef Biogrid Interaction: ARHGDIA — RAC1 (direct interaction, two hybrid) Fauré et al., Biochimie 2001*
• IRef Biogrid Interaction: ARHGDIA — RAC1 (direct interaction, two hybrid) Di-Poï et al., Biochemistry 2001*
• IRef Biogrid Interaction: ARHGDIA — RAC1 (association, biochemical) Di-Poï et al., Biochemistry 2001*
• IRef Hprd Interaction: ARHGDIA — RAC1 (two hybrid) Newcombe et al., Biochemistry 1999*, Lian et al., Structure 2000*, Di-Poï et al., Biochemistry 2001*
• IRef Hprd Interaction: ARHGDIA — RAC1 (in vivo) Newcombe et al., Biochemistry 1999*, Lian et al., Structure 2000*, Di-Poï et al., Biochemistry 2001*
• IRef Hprd Interaction: ARHGDIA — RAC1 (in vitro) Newcombe et al., Biochemistry 1999*, Lian et al., Structure 2000*, Di-Poï et al., Biochemistry 2001*
• IRef Intact Interaction: RAC1 — ARHGDIA (direct interaction, x-ray crystallography) Grizot et al., Biochemistry 2001*
• IRef Intact Interaction: RAC1 — ARHGDIA (physical association, anti bait coimmunoprecipitation) Ewing et al., Molecular systems biology 2007
• IRef Intact Interaction: RAC1 — ARHGDIA (physical association, pull down) ten Klooster et al., EMBO J 2007*
• IRef Intact Interaction: RAC1 — ARHGDIA (physical association, two hybrid) Vinayagam et al., Science signaling 2011
• IRef Intact Interaction: RAC1 — ARHGDIA (physical association, pull down) Navarro-Lérida et al., EMBO J 2012*
• IRef Intact Interaction: RAC1 — ARHGDIA (physical association, anti tag coimmunoprecipitation) Navarro-Lérida et al., EMBO J 2012*
• IRef Ophid Interaction: RAC1 — ARHGDIA (aggregation, confirmational text mining) Lian et al., Structure 2000*
• IRef Ophid Interaction: RAC1 — ARHGDIA (aggregation, interologs mapping) Brown et al., Bioinformatics 2005

Text-mined interactions from Literome

Qi et al., Cardiovasc Res 2008 : A decrease in Rho-GDIalpha expression by using target small interfering RNA ( siRNA ) transfection caused increases in the phosphorylation of Rac1 and Akt and enhancements of VSMC migration and apoptosis
Dovas et al., J Biol Chem 2010 : Here, it is demonstrated that conventional PKC phosphorylates RhoGDIalpha on serine 34, resulting in a specific decrease in affinity for RhoA but not Rac1 or Cdc42