Gene interactions and pathways from curated databases and text-mining

◀ Back to RHOA

ARHGEF28 — RHOA

Pathways - manually collected, often from reviews:

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

Text-mined interactions from Literome

van Horck et al., J Biol Chem 2001 : When overexpressed in intact cells, however, p190RhoGEF does activate RhoA with subsequent F-actin reorganization and serum response factor mediated transcription ... Our results indicate that p190RhoGEF is a specific activator of RhoA that requires as yet unknown binding partners to unmask its GDP/GTP exchange activity in vivo, and they suggest that p190RhoGEF may provide a link between microtubule dynamics and RhoA signaling
Ellerbroek et al., J Biol Chem 2003 : RhoA phosphorylation or phosphomimetic substitution did not affect Rho guanine nucleotide exchange factor , GTPase activating protein, or geranylgeranyl transferase activity in vitro but promoted binding to the Rho guanine-dissociation inhibitor as measured by exchange factor competition assays
Zhai et al., J Biol Chem 2003 : Neuro-2a cell binding to laminin increased endogenous FAK and p190RhoGEF tyrosine phosphorylation, and co-transfection of a dominant negative inhibitor of FAK activity, termed FRNK, inhibited lamininstimulated p190RhoGEF tyrosine phosphorylation and p21 RhoA GTP binding
Lim et al., J Cell Biol 2008 : p190RhoGEF overexpression enhances RhoA activation and FA formation in MEFs dependent on FAK binding and associated with p190RhoGEF FA recruitment and tyrosine phosphorylation
Aittaleb et al., Cell Signal 2009 : Leukemia associated Rho guanine nucleotide exchange factor ( LARG ) activates RhoA in response to signals received by specific classes of cell surface receptors