◀ Back to RHOA
ARHGEF28 — RHOA
Pathways - manually collected, often from reviews:
-
NCI Pathway Database Regulation of RhoA activity:
p190RHOGEF (ARHGEF28)
→
RHOA/GTP complex (RHOA)
(modification, activates)
van Horck et al., J Biol Chem 2001
Evidence: assay
-
NCI Pathway Database Regulation of RhoA activity:
p190RHOGEF (ARHGEF28)
→
RHOA/GDP complex (RHOA)
(modification, activates)
van Horck et al., J Biol Chem 2001
Evidence: assay
-
NCI Pathway Database Signaling events mediated by focal adhesion kinase:
p190RHOGEF (ARHGEF28)
→
RHOA/GTP complex (RHOA)
(modification, activates)
van Horck et al., J Biol Chem 2001, Zhai et al., J Biol Chem 2003, Lim et al., J Cell Biol 2008*
Evidence: mutant phenotype, assay
-
NCI Pathway Database Signaling events mediated by focal adhesion kinase:
p190RHOGEF (ARHGEF28)
→
RHOA/GDP complex (RHOA)
(modification, activates)
van Horck et al., J Biol Chem 2001, Zhai et al., J Biol Chem 2003, Lim et al., J Cell Biol 2008*
Evidence: mutant phenotype, assay
-
Reactome Reaction:
RHOA
→
ARHGEF28
(indirect_complex)
van Horck et al., J Biol Chem 2001
-
Reactome Reaction:
RHOA
→
ARHGEF28
(reaction)
van Horck et al., J Biol Chem 2001
Protein-Protein interactions - manually collected from original source literature:
Studies that report less than 10 interactions are marked with *
Text-mined interactions from Literome
van Horck et al., J Biol Chem 2001
:
When overexpressed in intact cells, however,
p190RhoGEF does
activate RhoA with subsequent F-actin reorganization and serum response factor mediated transcription ... Our results indicate that
p190RhoGEF is a specific
activator of
RhoA that requires as yet unknown binding partners to unmask its GDP/GTP exchange activity in vivo, and they suggest that p190RhoGEF may provide a link between microtubule dynamics and RhoA signaling
Ellerbroek et al., J Biol Chem 2003
:
RhoA phosphorylation or phosphomimetic substitution did not
affect Rho guanine nucleotide exchange factor , GTPase activating protein, or geranylgeranyl transferase activity in vitro but promoted binding to the Rho guanine-dissociation inhibitor as measured by exchange factor competition assays
Zhai et al., J Biol Chem 2003
:
Neuro-2a cell binding to laminin increased endogenous FAK and
p190RhoGEF tyrosine phosphorylation, and co-transfection of a dominant negative inhibitor of FAK activity, termed FRNK,
inhibited lamininstimulated p190RhoGEF tyrosine phosphorylation and p21
RhoA GTP binding
Lim et al., J Cell Biol 2008
:
p190RhoGEF overexpression
enhances RhoA activation and FA formation in MEFs dependent on FAK binding and associated with p190RhoGEF FA recruitment and tyrosine phosphorylation
Aittaleb et al., Cell Signal 2009
:
Leukemia associated
Rho guanine nucleotide exchange factor ( LARG )
activates RhoA in response to signals received by specific classes of cell surface receptors