Sekine et al., J Biol Chem 2006
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In contrast, we observed clear functional differences in the ability of Arnt and Arnt2 to induce xenobiotic response element-driven reporter and endogenous CYP1A1 gene expression
Dougherty et al., Toxicological sciences : an official journal of the Society of Toxicology 2008
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ARNT2 expressed in Hepa-1 cell culture lines with reduced ARNT protein resulted in minimal induction of endogenous CYP1A1 protein compared to cells expressing ARNT, and mutation of the putative proline residue at amino acid 352 to histidine failed to produce an ARNT2 that could function in AHR mediated signaling ... However, the expression of ARNT2 in wild-type Hepa-1 cells reduced TCDD mediated induction of endogenous CYP1A1 protein by 30 %, even though AHR*ARNT2 complexes could not be detected in nuclear extracts