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ARSK — CRK

Text-mined interactions from Literome

Takeda et al., J Biol Chem 2000 : ASK1DeltaN induced neurite outgrowth was strongly inhibited by treatment with the p38 inhibitor SB203580 but not with the MEK inhibitors, suggesting that activation of p38 , rather than of ERK, is required for the neurite inducing activity of ASK1 in PC12 cells
Hatai et al., J Biol Chem 2000 : ASK1 activates JNK and p38 mitogen activated protein kinases and constitutes a pivotal signaling pathway in cytokine- and stress induced apoptosis
Yamagishi et al., J Biochem 2003 : Here, we examined whether ASK1 is involved in the activation of p38 in the low potassium ( LK ) -induced apoptosis of cerebellar granule neurons
Hsieh et al., FASEB J 2006 (MAP Kinase Signaling System) : Thioredoxin-ASK1 complex levels regulate ROS mediated p38 MAPK pathway activity in livers of aged and long lived Snell dwarf mice
Basu et al., J Biol Chem 2007 (MAP Kinase Signaling System...) : ASK1 activates the MAPKs p38 and JNK
Hassan et al., Hepatology 2009 (Hepatitis C, Chronic...) : In addition, regulated expression of core protein in HepG2 or Huh7 cells was found to induce expression and activation of the transcription factor E2F1 and apoptosis signal regulating kinase 1 ( ASK1 ), activation of c-jun-N-terminal kinase ( JNK ) and p38 , and extracellular regulated kinase (ERK), and transcription factors activator protein 1 (AP-1), activating transcription factor 2 ( ATF-2 ), cyclic adenosine monophosphate response element binding ( CREB ), E2F1, hypoxia inducing factor 1 alpha ( HIF-1alpha ), and specificity protein 1
Tran et al., J Biol Chem 2012 (MAP Kinase Signaling System) : In agreement with this, overexpression of ASK1 or TAK1 resulted in enhanced p38MAPK activation, and their knockdown inhibited p38MAPK in C2C12 cells
Shiizaki et al., Adv Biol Regul 2013 (Anoxia) : ASK1 activates c-jun N-terminal kinase ( JNK ) and p38 in response to various stimuli such as oxidative stress, endoplasmic reticulum stress, infection and calcium influx