Gene interactions and pathways from curated databases and text-mining

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BAD — PIK3R1

Text-mined interactions from Literome

Mehrhof et al., Circulation 2001 : IGF-I-stimulation was followed by a PI3K dependent phosphorylation of AKT and BAD and an MEK1 dependent phosphorylation of extracellular signal regulated kinase ( ERK ) 1 and ERK2
Raufman et al., J Cell Physiol 2008 (Colonic Neoplasms) : DCT induced PI3K/Akt activation resulted in downstream phosphorylation of GSK-3 ( Ser ( 21/9 ) ) and BAD ( Ser ( 136 ) ), and nuclear translocation ( activation ) of NF-kappaB, thereby confirming that DCT induced activation of PI3K/Akt signaling regulates both proproliferative and prosurvival signals
Smith et al., PloS one 2009 (Prostatic Neoplasms) : Thus, activation of EGFR, GPCRs or PI3K pathway leads to BAD phosphorylation and inhibition of apoptosis