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BAD — PIK3R1
Text-mined interactions from Literome
Mehrhof et al., Circulation 2001
:
IGF-I-stimulation was followed by a
PI3K dependent phosphorylation of AKT and
BAD and an MEK1 dependent phosphorylation of extracellular signal regulated kinase ( ERK ) 1 and ERK2
Raufman et al., J Cell Physiol 2008
(Colonic Neoplasms) :
DCT induced
PI3K/Akt activation
resulted in downstream phosphorylation of GSK-3 ( Ser ( 21/9 ) ) and
BAD ( Ser ( 136 ) ), and nuclear translocation ( activation ) of NF-kappaB, thereby confirming that DCT induced activation of PI3K/Akt signaling regulates both proproliferative and prosurvival signals
Smith et al., PloS one 2009
(Prostatic Neoplasms) :
Thus, activation of EGFR, GPCRs or
PI3K pathway
leads to
BAD phosphorylation and inhibition of apoptosis