Gene interactions and pathways from curated databases and text-mining

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BAX — PIK3R1

Text-mined interactions from Literome

Parikh et al., J Immunol 2004 : Because inhibition of PI3K or its target Akt also triggers mitochondrial translocation of Bax in T cells and apoptosis in Bax transfected cell lines, we generated Bax deletion mutants to identify the region ( s ) that confers sensitivity to regulation by MEK1 and Akt
Iwase et al., Int J Oncol 2007 (Carcinoma, Squamous Cell...) : Expression of Bcl-2, cellular inhibitor of apoptosis protein-1 ( cIAP-1 ), and X-linked IAP was down-regulated, and expression of Bax was up-regulated by PI 3-K inhibitors, while that of Bcl-xL, Bak and cIAP-2 was not attenuated
Kim et al., Mol Cancer Res 2008 (MAP Kinase Signaling System...) : Inhibition of PI3K also suppressed SEK-1/MKK-4 and JNK activation, Bax and Bak activation, and Bcl-2 down-regulation
Kolliputi et al., Am J Physiol Lung Cell Mol Physiol 2009 (Acute Lung Injury...) : IL-6 cytoprotection in hyperoxic acute lung injury occurs via PI3K/Akt mediated Bax phosphorylation ... Thus IL-6 functions in a cytoprotective manner, in part, by suppressing Bax translocation and dimerization through PI3K/Akt mediated Bax phosphorylation
Zhang et al., Int J Radiat Oncol Biol Phys 2012 (Lung Injury...) : Apoptosis correlated with increased PTEN expression, inhibition of downstream PI3K/AKT signaling, and increased p53 and Bax protein levels
Wang et al., Toxicol Lett 2013 (Cardiovascular Diseases) : In addition, the PI3K inhibitor partially blocked the effects of Sal B on the upregulation of Bcl-2 and Bcl-xl protein expression, and downregulation of Bax protein expression