◀ Back to PIK3R1
BCL10 — PIK3R1
Text-mined interactions from Literome
Sade et al., Eur J Immunol 2003
:
Thus, IL-7 regulates IAP-2 expression and
inhibits dexamethasone induced apoptosis by activating Akt via
PI3K dependent signaling, but regulates
Bcl-x ( L ) expression via a PI3K independent pathway in mature T cells
Kozuma et al., Journal of thrombosis and haemostasis : JTH 2007
:
We thus hypothesized that
PI3 K inhibits the activation of caspase-3 and consequent cleavage of
Bcl-xL
Elsegood et al., Arterioscler Thromb Vasc Biol 2009
:
MEK1/2 and
PI3K activities were also
required for oxLDL induced Bcl-2 and
Bcl-x ( L ) mRNA upregulation
Wang et al., Cancer Lett 2010
(Ovarian Neoplasms) :
Meanwhile, the further study demonstrates that the chemoresistance caused by IL-6 is associated with increased expression of both multidrug resistance related genes ( MDR1 and GSTpi ) and apoptosis inhibitory proteins ( Bcl-2,
Bcl-xL and XIAP ), as well as
activation of Ras/MEK/ERK and
PI3K/Akt signaling
Marion et al., Dev Cell 2012
:
Depletion of
Bcl10 impaired Rac1 and
PI3K activation and led to an abortive phagocytic cup rich in PI ( 4,5 ) P ( 2 ), Cdc42, and F-actin, which could be rescued with low doses of F-actin depolymerizing drugs
Wang et al., Toxicol Lett 2013
(Cardiovascular Diseases) :
In addition, the
PI3K inhibitor partially
blocked the effects of Sal B on the upregulation of Bcl-2 and
Bcl-xl protein expression, and downregulation of Bax protein expression
Rahmani et al., Cancer Res 2013
(Leukemia, Myeloid) :
PI3K/mTOR inhibitors markedly downregulated Mcl-1 but
increased Bim binding to
Bcl-2/Bcl-xL ; the latter effect was abrogated by ABT-737