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BCL2 — PIK3R1
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Honda et al., J Neurosci Res 2001
(Alzheimer Disease...) :
Furthermore, 17beta-estradiol induced phosphorylation of the cAMP response element binding protein ( CREB ) at Ser ( 133 ) within 15 min and then upregulated
Bcl-2 in a
PI3-K/Akt dependent manner
Bernabé et al., Exp Cell Res 2001
(MAP Kinase Signaling System) :
Thus, we propose that exposure to apoptotic concentrations of NO triggers ERK- and p38 dependent cytochrome c release, caspase 3 activation, and
PI3K dependent
Bcl-2 phosphorylation
Barata et al., Leukemia & lymphoma 2005
(Leukemia-Lymphoma, Adult T-Cell) :
PI3K signaling is
required for the induction of
Bcl-2 , the down-regulation of p27 ( kip1 ) and cell cycle progression
Kozuma et al., Journal of thrombosis and haemostasis : JTH 2007
:
We thus hypothesized that
PI3 K inhibits the activation of caspase-3 and consequent cleavage of
Bcl-xL
Iwase et al., Int J Oncol 2007
(Carcinoma, Squamous Cell...) :
Expression of
Bcl-2 , cellular inhibitor of apoptosis protein-1 ( cIAP-1 ), and X-linked IAP was down-regulated, and expression of Bax was
up-regulated by
PI 3-K inhibitors, while that of Bcl-xL, Bak and cIAP-2 was not attenuated
Lim et al., J Neurosci Res 2008
:
Thus, MAPK/ERK dependent p35 up-regulation and MAPK/ERK dependent and
PI3K/Akt dependent
Bcl2 up-regulation contribute to BDNF stimulated neural differentiation and to the survival of differentiated cells
Creson et al., J Mol Neurosci 2009
(MAP Kinase Signaling System...) :
Evidence for
involvement of ERK,
PI3K , and RSK in induction of
Bcl-2 by valproate
Zhang et al., Exp Brain Res 2009
:
The importance of the PI3K pathway was further confirmed by the activation of Akt and anti-apoptotic
Bcl-2 by cryptotanshinone in a
PI3K dependent manner
Kim et al., Mol Cancer Res 2008
(MAP Kinase Signaling System...) :
Inhibition of
PI3K also
suppressed SEK-1/MKK-4 and JNK activation, Bax and Bak activation, and
Bcl-2 down-regulation
Elsegood et al., Arterioscler Thromb Vasc Biol 2009
:
MEK1/2 and
PI3K activities were also
required for oxLDL induced
Bcl-2 and Bcl-x ( L ) mRNA upregulation
Chang et al., Biochem J 2009
(Ovarian Neoplasms) :
Thus mesothelin can inhibit paclitaxel induced cell death mainly by
involving PI3K signalling in the regulation of
Bcl-2 family expression
Wang et al., Cancer Lett 2010
(Ovarian Neoplasms) :
Meanwhile, the further study demonstrates that the chemoresistance caused by IL-6 is associated with increased expression of both multidrug resistance related genes ( MDR1 and GSTpi ) and apoptosis inhibitory proteins ( Bcl-2,
Bcl-xL and XIAP ), as well as
activation of Ras/MEK/ERK and
PI3K/Akt signaling
Bratton et al., Int J Oncol 2010
(Breast Neoplasms) :
Regulation of ERalpha mediated transcription of
Bcl-2 by
PI3K-AKT crosstalk : implications for breast cancer cell survival
Beaulieu et al., PloS one 2011
(Leukemia, Myelogenous, Chronic, BCR-ABL Positive) :
The effect of a-linolenic acids seemed to be due to
PI3K pathway and
Bcl-2 inhibition
Wang et al., Toxicol Lett 2013
(Cardiovascular Diseases) :
In addition, the
PI3K inhibitor partially
blocked the effects of Sal B on the upregulation of Bcl-2 and
Bcl-xl protein expression, and downregulation of Bax protein expression ... In addition, the
PI3K inhibitor partially
blocked the effects of Sal B on the upregulation of
Bcl-2 and Bcl-xl protein expression, and downregulation of Bax protein expression
Rahmani et al., Cancer Res 2013
(Leukemia, Myeloid) :
PI3K/mTOR inhibitors markedly downregulated Mcl-1 but
increased Bim binding to
Bcl-2/Bcl-xL ; the latter effect was abrogated by ABT-737 ...
PI3K/mTOR inhibitors markedly downregulated Mcl-1 but
increased Bim binding to
Bcl-2/Bcl-xL ; the latter effect was abrogated by ABT-737
Shukla et al., Neurotoxicology 2013
:
Sal toxicity coincided with reduced pAkt level and its downstream effectors : pCREB, pGSK-3ß,
Bcl-2 and neurotrophins GDNF, BDNF suggesting
repressed PI3K/Akt signaling