Gene interactions and pathways from curated databases and text-mining

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BCL2 — RUNX2

Text-mined interactions from Literome

Bellido et al., J Biol Chem 2003 (Bone Resorption) : Attenuation of apoptosis by PTH in cultured osteoblastic cells requires protein kinase A-mediated phosphorylation and inactivation of the pro-apoptotic protein Bad as well as transcription of survival genes, like Bcl-2 , mediated by CREB ( cAMP response element binding protein ) and Runx2
Browne et al., Br J Cancer 2012 (Prostatic Neoplasms) : Bicalutamide induced hypoxia potentiates RUNX2 mediated Bcl-2 expression resulting in apoptosis resistance ... RUNX2 expression was associated with increased Bcl-2 levels, and regulation of Bcl-2 by RUNX2 was confirmed through chromatin immunoprecipitation ( ChIP ) binding and reporter assays