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BCL2 — RUNX2
Text-mined interactions from Literome
Bellido et al., J Biol Chem 2003
(Bone Resorption) :
Attenuation of apoptosis by PTH in cultured osteoblastic cells requires protein kinase A-mediated phosphorylation and inactivation of the pro-apoptotic protein Bad as well as transcription of survival genes, like
Bcl-2 ,
mediated by CREB ( cAMP response element binding protein ) and
Runx2
Browne et al., Br J Cancer 2012
(Prostatic Neoplasms) :
Bicalutamide induced hypoxia potentiates
RUNX2 mediated
Bcl-2 expression resulting in apoptosis resistance ... RUNX2 expression was associated with increased Bcl-2 levels, and
regulation of
Bcl-2 by
RUNX2 was confirmed through chromatin immunoprecipitation ( ChIP ) binding and reporter assays