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BCR — MAPK4

Text-mined interactions from Literome

Swart et al., Biochem Biophys Res Commun 2000 : By contrast, we show that pretreatment of CH31 B cells with the highly specific p38 MAPK inhibitor SB203580 ablated both BCR induced p38 MAPK activity and apoptosis
Kawauchi et al., Int J Hematol 2002 (Leukemia, Lymphocytic, Chronic, B-Cell...) : In B-CLL cells, BCR cross linking neither induced activation nor enhanced the activities of Lyn, Syk, p21ras, JNK, p38 MAPK , or Akt kinases, whereas p38 MAPK and Akt were constitutively active
Grill et al., Blood 2002 (MAP Kinase Signaling System) : In contrast, Ly294002 partially inhibited the activation of p38 MAPK induced by cross linking of the BCR , although some p38 MAPK activation occurred in the absence of increases in the activity of Rac-1 or PI-3K
Taguchi et al., J Immunol 2003 (Burkitt Lymphoma...) : Pre-BCR cross linking induced prompt and strong activation of extracellular signal regulated kinase 1, whereas CD24 cross linking induced the sustained activation of p38 MAPK , following weak extracellular signal regulated kinase 1 activation
Ahn et al., Blood 2006 : Reduction of LIME expression by the introduction of siRNA resulted in the disruption of BCR mediated activation of MAPK , calcium flux, NF-AT, PI3K, and NF-kappaB
Ke et al., J Biol Chem 2006 (Lymphoma, B-Cell...) : BCR induced MAPK activation was modest and transient with a small increase in egr-1 expression in normal immature B cells consistent with their inability to proliferate in response to BCR cross linking
Chu et al., Cancer Res 2007 (Cell Transformation, Neoplastic...) : BCR/ABL expression results in enhanced Ras and Akt activity but reduced mitogen activated protein kinase activity in human hematopoietic cells, which is reversed by BCR/ABL-Y177 mutation
Chew et al., J Biol Chem 2007 : The overexpression of LPXN in mouse A20 B lymphoma cells led to the suppression of BCR induced activation of JNK, p38 MAPK , and, to a lesser extent, Akt, but not ERK and NFkappaB, suggesting that LPXN can selectively repress BCR signaling
McCabe et al., Toxicological sciences : an official journal of the Society of Toxicology 2007 : Using Western blotting and phospho-specific flow cytometry, we now show that the kinetics and magnitude of BCR mediated activation of ERK-MAPK are markedly attenuated in WEHI-231 cells and splenic B cells that have been exposed to low and nontoxic burdens of Hg ( +2 )
Gross et al., J Immunol 2009 : Wild-type mature follicular B cells were less sensitive to BCR stimulation than were immature transitional stage 1 B cells with regard to BCR induced calcium elevation and ERK MAPK activation
Modi et al., Leukemia 2011 (Cell Transformation, Neoplastic...) : Inhibition of Grb2 expression demonstrates an important role in BCR-ABL mediated MAPK activation and transformation of primary human hematopoietic cells ... We conclude that inhibition of Grb2 expression demonstrates an important role in BCR-ABL mediated MAPK activation and transformation of primary human hematopoietic cells.These results support further investigation of downstream effectors of Grb2 mediated signals and targeting of Grb2 interactions in the treatment of CML
Redig et al., Leukemia & lymphoma 2011 (Leukemia, Myelogenous, Chronic, BCR-ABL Positive) : A large body of evidence has established that BCR-ABL regulates engagement and activation of mammalian target of rapamycin (mTOR) and mitogen activated protein kinase ( MAPK ) signaling cascades
Raitano et al., Proc Natl Acad Sci U S A 1995 (Cell Transformation, Neoplastic...) : To examine subsequent signal transduction events we measured the effect of Bcr-Abl on two mitogen activated protein kinase ( MAPK ) cascades -- the extracellular signal regulated kinase ( ERK ) pathway and the Jun N-terminal kinase (JNK) pathway
Salmon et al., J Immunol 1997 : Cross linking of the B cell Ag receptor (BCR) or CD40 on freshly isolated or LPS activated splenic B cells or the immature B lymphoma, WEHI 231, resulted in activation of p38 MAPK and MAPKAP kinase-2 ... We conclude that the activation of p38 MAPK and MAPKAP kinase-2 by cross linking of the TCR, BCR , Fas, or CD40 was not correlated with their roles in regulating lymphocyte survival, and that suppression of kinase activity did not inhibit the induction of apoptosis
Graves et al., J Immunol 1998 (Lymphoma, B-Cell) : To determine the role of p38 MAPK activation in BCR- and Fas induced apoptosis, we employed SB203580, a specific inhibitor of p38 MAPK
Jiang et al., J Exp Med 1998 : BCR cross linking in the chicken DT40 B cell line also activates three distinct mitogen activated protein kinases ( MAPKs ) : extracellular signal regulated kinase ( ERK ) 2, c-jun NH2-terminal kinase ( JNK ) 1, and p38 MAPK ... In contrast, BCR mediated p38 MAPK activation was detected in all three PTK-deficient cells, suggesting that no single PTK is essential ... However, BCR mediated p38 MAPK activation was abolished in Lyn/Syk double deficient cells, demonstrating that either Lyn or Syk alone may be sufficient to activate p38 MAPK ... Our data show that BCR mediated MAPK activation is regulated at the level of the PTKs
Liu et al., J Exp Med 1998 : Ship-/- splenic B cells displayed prolonged Ca2+ influx, increased proliferation in vitro, and enhanced mitogen activated protein kinase ( MAPK ) activation in response to BCR-FcgammaRIIB coligation