Gene interactions and pathways from curated databases and text-mining

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BDNF — EPO

Text-mined interactions from Literome

Viviani et al., J Neurochem 2005 : These data demonstrate that erythropoietin activates the CREB transcription pathway and increases BDNF expression and production, which contributes to erythropoietin mediated neuroprotection
Zhang et al., J Neurosci Res 2006 (Brain Ischemia...) : EPO also enhanced the CA1 level of brain derived neurotrophic factor
Sönmez et al., Surg Neurol 2007 (Spinal Cord Ischemia) : Recent studies have suggested that EPO activates the CREB transcription pathway and increases BDNF expression and production, which contributes to EPO mediated neuroprotection
Girgenti et al., Biol Psychiatry 2009 (Disease Models, Animal...) : Gene expression profiles revealed that EPO induces the expression of neurotrophic genes such as brain derived neurotrophic factor , VGF ( nonacronymic ), and neuritin
Wu et al., Neurobiol Dis 2010 : Erythropoietin and sonic hedgehog mediate the neuroprotective effects of brain derived neurotrophic factor against mitochondrial inhibition ... We found that BDNF induced EPO expression at both mRNA and protein levels
Hu et al., Front Biosci (Elite Ed) 2011 (Diabetes Mellitus, Experimental...) : The results showed that intravitreal EPO ameliorated the up-regulation of GFAP and vimentin in the diabetic retina evaluated by immunofluorescence and Western blotting ; but up-regulated BDNF and CNTF expressions, quantified by real-time PCR and ELISA, in the 24-week diabetic rat retinas