◀ Back to NOTCH1
BMP2 — NOTCH1
Text-mined interactions from Literome
Sciaudone et al., Endocrinology 2003
:
In the
presence of
bone morphogenetic protein-2 (BMP-2) , ST-2 cells differentiated toward osteoblasts forming mineralized nodules, and
Notch 1 opposed this effect and decreased the expression of osteocalcin, type I collagen, and alkaline phosphatase transcripts and Delta2Delta FosB protein
de Jong et al., Biochem Biophys Res Commun 2004
:
Notably, our data show that three
Notch signal transduction pathway genes, Lfng, Hey1, and Hes1, are differentially
regulated by
BMP2 and TGF-beta
Nobta et al., J Biol Chem 2005
:
Furthermore, our data also suggest that functional
Notch signaling is
essential not only for BMP2 induced osteoblast differentiation but also for
BMP signaling itself
Chen et al., Nat Biotechnol 2008
:
Microarray analyses reveal that this respecification is mediated in part through the coordinated
regulation of the
BMP and Wnt pathways by
Notch signaling
Luna-Zurita et al., J Clin Invest 2010
:
Notch1 activation in myocardium extends Hey1 expression to nonchamber myocardium,
represses Bmp2 , and impairs EMT
Morikawa et al., Nucleic Acids Res 2011
:
Furthermore, we characterized EC-specific Smad1/5 target genes and found that several
Notch signaling pathway related genes were
induced by
BMP in ECs
Larman et al., Cell Signal 2012
:
Interestingly, our gene profiling analysis shows that
BMP signaling
activates a number of
Notch regulated transcription factors, including HEY1
Laurent et al., Dev Neurobiol 2012
:
In retinal neurons and Müller cell cultures, CCN3 expression is
induced by activated
BMP signaling, whereas
Notch signaling decreases CCN3 mRNA and protein levels in Müller cells and has no effect in retinal neurons
Phillips et al., Toxicol Appl Pharmacol 2013
:
Inhibition of
Notch1 activation
blocked BMP induction of keratins 1 and 10, while FOXN1 induction was largely unaffected ... Supporting a requirement for Notch1 signaling in keratin induction,
BMP increased levels of activated
Notch1 , which was blocked by arsenite ... Knockdown also decreased activated
Notch1 , keratin 1 and keratin 10 protein levels, both in the
presence and absence of
BMP