Gene interactions and pathways from curated databases and text-mining

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BMP6 — PIK3R1

Text-mined interactions from Literome

Mandal et al., Endocrinology 2009 : Inhibition of PI3K/Akt signaling blocked the binding of Smads 1/5 to the CSF-1 BMP-responsive element present in the CSF-1 promoter, resulting in attenuation of Smad dependent CSF-1 transcription
Perron et al., Neural development 2011 : BMP6 , which evokes neural induction but does not have orienting activity, activates Smad signaling but does not stimulate PI3K
Ueki et al., Glia 2013 : Interestingly, BMP/Smad1/5/8 activation downstream of PI3K/AKT signaling was also necessary for robust Müller glial proliferation, though activation of BMP/Smad1/5/8 signaling alone failed to stimulate their proliferation