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BRCA1 — MYC

Pathways - manually collected, often from reviews:

• NCI Pathway Database Validated targets of C-MYC transcriptional repression: BRCA1 (BRCA1) → MYC/Max complex (MYC-MAX) (transcription, inhibits) Kennedy et al., Cancer Res 2005*
  Evidence: mutant phenotype, reporter gene, physical interaction

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

• IRef Bind Interaction: Complex of BRCA1-MYC-NMI Li et al., J Biol Chem 2002*
• IRef Bind Interaction: MYC — BRCA1 Li et al., J Biol Chem 2002*, Wang et al., Oncogene 1998*
• IRef Bind_translation Interaction: BRCA1 — MYC (affinity chromatography technology) Wang et al., Oncogene 1998*
• IRef Bind_translation Interaction: BRCA1 — MYC (two hybrid) Wang et al., Oncogene 1998*
• IRef Bind_translation Interaction: BRCA1 — MYC (coimmunoprecipitation) Wang et al., Oncogene 1998*
• IRef Bind_translation Interaction: BRCA1 — MYC (affinity chromatography technology) Li et al., J Biol Chem 2002*, Wang et al., Oncogene 1998*
• IRef Biogrid Interaction: MYC — BRCA1 (direct interaction, two hybrid) Xiong et al., Mol Cell Biol 2003*
• IRef Biogrid Interaction: MYC — BRCA1 (physical association, affinity chromatography technology) Harte et al., Cancer Res 2010*
• IRef Biogrid Interaction: MYC — BRCA1 (physical association, affinity chromatography technology) Xiong et al., Mol Cell Biol 2003*
• IRef Biogrid Interaction: MYC — BRCA1 (physical association, affinity chromatography technology) Zhou et al., Biochem Biophys Res Commun 2003*
• IRef Biogrid Interaction: MYC — BRCA1 (physical association, affinity chromatography technology) Li et al., J Biol Chem 2002*
• IRef Biogrid Interaction: MYC — BRCA1 (colocalization, imaging technique) Xiong et al., Mol Cell Biol 2003*
• IRef Biogrid Interaction: MYC — BRCA1 (direct interaction, two hybrid) Wang et al., Oncogene 1998*
• IRef Biogrid Interaction: MYC — BRCA1 (direct interaction, pull down) Wang et al., Oncogene 1998*
• IRef Biogrid Interaction: MYC — BRCA1 (physical association, affinity chromatography technology) Wang et al., Oncogene 1998*
• IRef Biogrid Interaction: MYC — BRCA1 (direct interaction, two hybrid) Harte et al., Cancer Res 2010*
• IRef Dip Interaction: MYC — BRCA1 (physical association, coimmunoprecipitation) Wang et al., Oncogene 1998*
• IRef Dip Interaction: MYC — BRCA1 (physical association, two hybrid) Wang et al., Oncogene 1998*
• IRef Dip Interaction: MYC — BRCA1 (physical association, affinity chromatography technology) Wang et al., Oncogene 1998*
• IRef Hprd Interaction: BRCA1 — MYC (in vivo) Zhou et al., Biochem Biophys Res Commun 2003*, Wang et al., Oncogene 1998*
• IRef Hprd Interaction: BRCA1 — MYC (two hybrid) Zhou et al., Biochem Biophys Res Commun 2003*, Wang et al., Oncogene 1998*
• IRef Hprd Interaction: BRCA1 — MYC (in vitro) Zhou et al., Biochem Biophys Res Commun 2003*, Wang et al., Oncogene 1998*
• IRef Ophid Interaction: MYC — BRCA1 (aggregation, interologs mapping) Brown et al., Bioinformatics 2005

Text-mined interactions from Literome

Li et al., J Biol Chem 2002 (Breast Neoplasms) : Although Nmi or BRCA1 alone had no effect on c-Myc induced hTERT promoter activity, BRCA1 together with Nmi significantly inhibited this c-Myc induced hTERT promoter activity ( approximately 75 % inhibition )
Kennedy et al., Cancer Res 2005 (Breast Neoplasms) : Furthermore, we show that BRCA1 and c-Myc form a complex on the psoriasin promoter and that BRCA1 mediated repression of psoriasin is dependent on functional c-Myc
Katiyar et al., Mol Endocrinol 2009 : However, BRCA1 overexpression inhibited the R5020 induced recruitment of PR to the c-Myc and mouse mammary tumor virus progesterone response elements (PREs) and blocked R5020 stimulated c-Myc expression, whereas BRCA1 underexpression did the opposite
Chen et al., BMC cancer 2011 (Adenocarcinoma...) : c-Myc activates BRCA1 gene expression through distal promoter elements in breast cancer cells ... In this report, we used cultured breast cancer cells to examine the mechanisms of transcriptional activation of BRCA1 by c-Myc ... Depletion of c-Myc decreased BRCA1 promoter activity, while ectopically expressed c-Myc increased BRCA1 promoter activity
Xu et al., Genes & cancer 2010 : Tumor suppressor BRCA1 inhibits MYC 's transcriptional and transforming activity