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C1QA — IL10

Text-mined interactions from Literome

Baruah et al., J Leukoc Biol 2006 : C1q increases the phagocytosis of apoptotic cells by DC and the release of interleukin-12 in the presence of TLR4 ligands and apoptotic cells ; PTX3 inhibits both events
Benoit et al., J Immunol 2012 : C1q bound to autologous apoptotic lymphocytes modulated expression of genes associated with JAK/STAT signaling, chemotaxis, immunoregulation, and NLRP3 inflammasome activation in LPS stimulated HMDMs. Specifically, C1q sequentially induced type I IFNs, IL-27, and IL-10 in LPS stimulated HMDMs and IL-27 in HMDMs when incubated with apoptotic lymphocyte conditioned media
Bottazzi et al., J Biol Chem 1997 : The capacity to bind C1q , mediated by the pentraxin domain, is consistent with the view that PTX3, produced in tissues by endothelial cells or macrophages in response to interleukin-1 and tumor necrosis factor, may act as a local regulator of innate immunity