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C5 — PI3

Text-mined interactions from Literome

Hila et al., Glia 2001 (Polyradiculoneuropathy) : PI-3 kinase-Akt pathway activation by C5b-9 induced, within 15 min, a 6.34 +/- 1.2-fold increase in BAD phosphorylation at Ser 136, but not at Ser 112
Fosbrink et al., J Biol Chem 2006 (Atherosclerosis...) : We have shown that C5b-9 induces proliferation and activates phosphatidylinositol 3-kinase (PI3K) , but it is unknown whether this can lead to activation of Akt in AEC, a major downstream target of PI3K, or if C5b-9 can induce the migration of AEC, a critical step in angiogenesis
Niculescu et al., Atherosclerosis 1999 : Both PI 3-kinase and p70 S6 kinase were activated by C5b-9 but not by C5b6