Gene interactions and pathways from curated databases and text-mining

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CALM1 — CALM3

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

Text-mined interactions from Literome

Tamura et al., Cancer 2000 (Carcinoma, Hepatocellular...) : Ca ( 2+ ) /calmodulin dependent CaM-kinase IV activity was high in HCC and showed almost no difference in activity in specimens with and without CaM-kinase kinase phosphorylation
Wu et al., J Physiol 2001 : 1. Ca2+-calmodulin dependent protein kinase II ( CaMK ) and a calmodulin (CaM) binding ` IQ ' domain ( IQ ) are both implicated in Ca2+ dependent regulation of L-type Ca2+ current ( I ( Ca ) )
Dupont et al., Cell Calcium 2003 : The rules that govern the activation and autophosphorylation of the multifunctional Ca2+-calmodulin kinase II ( CaMKII ) by Ca2+ and calmodulin (CaM) are thought to underlie its ability to decode Ca2+ oscillations and to control multiple cellular functions
Apel et al., J Biol Chem 1991 : Calmodulin inhibition of casein kinase II phosphorylation was due to calmodulin binding to neuromodulin rather than to the protein kinase
Lavialle-Defaix et al., J Pharmacol Exp Ther 2010 (Ion Channel Gating) : Furthermore, we demonstrated that activation of CaM-kinase II by intracellular calcium via the calcium-calmodulin complex affected the sensitivity of INa2 channels to DCJW
Yokoyama et al., Cell Calcium 1989 : Ca2+/calmodulin dependent activation of CaM-PPase was antagonized by inhibitors of calmodulin action, such as W-7 and trifluoperazine
Alexander et al., J Biol Chem 1987 : CaM decreased the rate of phosphorylation of P-57 by protein kinase C, and phosphorylation prevented P-57 binding to calmodulin-Sepharose
Jett et al., Arch Biochem Biophys 1987 : These data indicate that the membrane bound, calmodulin dependent protein kinase that phosphorylates phospholamban in cardiac membranes is not a specific calmodulin dependent kinase, but resembles the multifunctional Ca2+/CaM-kinase II
Pegova et al., Biokhimiia 1986 : [ The role of calmodulin ( delta-subunit ) in the activation of phosphorylase kinase from rabbit skeletal muscles ]
Cox et al., Arch Biochem Biophys 1987 : The activation of phosphorylase kinase ( EC 2.7.1.38 ; ATP : phosphorylase b phosphotransferase ) by the catalytic subunit of cAMP dependent protein kinase ( EC 2.7.1.37 ; ATP : protein phosphotransferase ) is inhibited by calmodulin
Widmaier et al., Endocrinology 1987 (Adrenal Gland Neoplasms) : Calmodulin binding was inhibited by competition with unlabeled calmodulin and by an inhibitor of calmodulin ( trifluoperazine )
Friedman et al., Biochem Biophys Res Commun 1986 : PK-CaM , using casein as exogenous substrate, was not stimulated by Ca2+ ( 0-500 microM ) or calmodulin ( 1-10 micrograms ) by themselves, but was stimulated by the combination of the two by 100 %
Tsutou et al., Biochem Biophys Res Commun 1985 : Calcium- and calmodulin dependent phosphorylase kinase activity in porcine uterine smooth muscle ... The physiological role of the calcium and calmodulin dependent activation of myometrium phosphorylase kinase is briefly discussed
Nikolaropoulos et al., Eur J Biochem 1985 : The gizzard phosphorylase kinase showed a high pH 6.8/8.2 activity ratio of 0.53, it was stimulated by Ca2+, inhibited up to 80 % by EGTA and it was activated about 1.9-fold by calmodulin
Furuya et al., Proc Natl Acad Sci U S A 1982 : The enzyme is also inactivated by phosphorylase kinase in the presence of Ca2+ and calmodulin
Cox et al., J Biol Chem 1982 : Calmodulin is shown to inhibit both the activation and phosphorylation of phosphorylase kinase by cAMP dependent protein kinase
Wang et al., J Biol Chem 1983 : It was shown to immunoprecipitate the calmodulin (CaM) dependent phosphodiesterase and phosphorylase kinase activities but not those of CaM itself, CaM independent phosphodiesterase and the catalytic unit of cAMP dependent protein kinase
Livanova et al., Biochem Int 1983 : Regulation of muscle phosphorylase kinase by actin and calmodulin ... There is evidence suggesting that the activation of phosphorylase kinase by actin is not due to trace contamination of actin preparations with calmodulin: (1) Troponin I and trifluoperazine inhibit the activation of phosphorylase kinase by calmodulin but do not inhibit the activation of phosphorylase kinase by F-actin ... ( 3 ) The activation of phosphorylase kinase by calmodulin and actin has different pH profiles
Erdödi et al., Int J Biochem 1984 : The stimulatory effect of heparin on the activity of nonactivated phosphorylase kinase is also expressed in the presence of calmodulin and glycogen
Silonova et al., Biokhimiia 1984 : [ Activation of phosphorylase kinase from rabbit muscle by actin and calmodulin ] ... There is evidence suggesting that the activation of phosphorylase kinase b by actin is not due to the presence of trace amounts of calmodulin in actin preparations : ( 1 ) Troponin I and trifluoperazine inhibit the activation of phosphorylase kinase by calmodulin but do not inhibit the activation by actin ... ( 3 ) The activation of phosphorylase kinase by calmodulin and actin has different pH profiles
Nakamura et al., FEBS Lett 1983 : Calcium -- calmodulin dependent activation of porcine liver phosphorylase kinase ... Porcine liver phosphorylase kinase was activated about 1.5-fold by calmodulin in a calcium dependent manner ... The physiological role of the calmodulin dependent activation for liver phosphorylase kinase is discussed
Gergely et al., Biochim Biophys Acta 1980 : The `` calcium dependent regulator '' or calmodulin can enhance the activity of phosphorylase kinase , increasing its affinity for Ca2+ ... In the presence of calmodulin phosphorylase kinase has only one, high affinity binding site for Ca2+ ( Ka = 0.27 microM )
Iida et al., Curr Genet 1995 : Calmodulin dependent protein kinase II and calmodulin are required for induced thermotolerance in Saccharomyces cerevisiae
Hohenegger et al., Biochem J 1993 : In the present study, we have examined the ability of the purified cardiac ryanodine receptor to serve as a substrate for phosphorylation by exogenously added catalytic subunit of the cyclic AMP ( cAMP ) -dependent protein kinase (PK-A), cyclic GMP ( cGMP ) -dependent protein kinase ( PK-G ), or calmodulin dependent protein kinase ( PK-CaM )
Stokoe et al., Biochem J 1993 : The catalytic domain was most similar ( 35-40 % identity ) to calmodulin dependent protein kinases II and IV, phosphorylase kinase , putative serine kinase H1 and the C-terminal domain of MAPKAP kinase-1, which form one branch of the protein kinase phylogenetic tree ... The catalytic domain was most similar ( 35-40 % identity ) to calmodulin dependent protein kinases II and IV, phosphorylase kinase , putative serine kinase H1 and the C-terminal domain of MAPKAP kinase-1, which form one branch of the protein kinase phylogenetic tree
Ivorra et al., Br J Pharmacol 1993 : Antioquine weakly inhibited some PDE forms isolated from bovine aorta : a CaM-PDE ( PDE I ) which preferentially hydrolyzes cyclic GMP and is activated by calmodulin , and a rolipram-sensitive cyclic AMP-PDE ( PDE IV ) which hydrolyzed cyclic AMP
Kawano et al., Circ Res 1993 : In the presence of calmodulin ( CaM, 0.1 mumol/L per microgram SR vesicles ), Ca2+ ( 3 mumol/L to 1 mmol/L ) added to the cis solution reduced the channel openings in a concentration dependent fashion, whereas Ca2+ ( 1 nmol/L to 1 mmol/L ) alone or CaM ( 0.1 to 1 mumol/L per microgram SR vesicles ) with 1 nmol/L Ca2+ did not affect the channel activity
Edlund et al., J Biol Chem 1996 : This suggests that calmodulin can regulate the functional activity of C-CAM
Ozbasli et al., Miner Electrolyte Metab 1996 : Calmodulin content in pancreatic islets and the response of islet membrane Ca2+ ATPase to calmodulin in phosphate depletion
de Freitas et al., Neurochem Res 1996 : Furthermore, exogenous Ca2+/calmodulin induced increased in vitro phosphorylation of the cytoskeletal proteins and CaM-KII activity only in the presence of calpastatin, suggesting the presence of Ca ( 2+ ) -induced calpain mediated proteolysis
Nadeau et al., J Biol Chem 1997 : The structural effects of endogenous and exogenous Ca2+/calmodulin on phosphorylase kinase