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CAPN14 — EGF
Text-mined interactions from Literome
Shiraha et al., J Cell Biol 1999
:
IP-10 also prevented
EGF- induced
calpain activation ( reduced by 71 +/- 7 % ) ... That this inhibition of EGF induced calpain activity was secondary to IP-10 initiating a cAMP-protein kinase A-calpain cascade is supported by the following evidence : ( a ) the cell permeant analogue 8- ( 4-chlorophenylthio ) -cAMP ( CPT-cAMP ) prevented EGF induced calpain activity and motility ; ( b ) other ELR negative CXC chemokines, monokine induced by IFN-gamma and platelet factor 4 that also generate cAMP, inhibited
EGF induced cell migration and
calpain activation ; and ( c ) the protein kinase A inhibitor Rp-8-Br-cAMPS abrogated IP-10 inhibition of cell migration, cell detachment, and calpain activation
Glading et al., J Biol Chem 2000
(MAP Kinase Signaling System) :
EGF induced rapid activation of
calpain that was preventable by molecular inhibition of the Ras-Raf-MEK but not phospholipase Cgamma signaling pathway, and calpain was stimulated by transfection of constitutively active MEK
Glading et al., J Biol Chem 2001
(MAP Kinase Signaling System) :
These data strongly suggest that
EGF induced
calpain activity can be enhanced near sites of membrane-proximal EGFR mediated ERK signaling, providing insights about how calpain activity might be regulated and targeted to enhance its effects on adhesion related substrates
Shiraha et al., Mol Cell Biol 2002
:
EGF induced
calpain activation was inhibited by cAMP activation of protein kinase A (PKA), as the PKA inhibitors H-89 and Rp-8Br-cAMPS abrogated cAMP inhibition of both motility and calpain activation ... cAMP suppressed
EGF induced
calpain activity of cells overexpressing a control wild-type human m-calpain ( 83 % +/- 3.7 % inhibition ) but only marginally suppressed that of cells expressing the PKA-resistant mutant human m-calpain ( 25 % +/- 5.5 % inhibition )
Glading et al., Mol Cell Biol 2004
(MAP Kinase Signaling System) :
We identified serine 50 as required for
epidermal growth factor (EGF) induced
calpain activation in vitro and in vivo ... Interestingly, EGF induced m-calpain activation occurs in the absence of increased intracellular calcium levels ;
EGF triggers
calpain even in the presence of intracellular calcium chelators and in calcium-free media
Shao et al., Mol Cell Biol 2006
:
Downregulation of phosphoinositide production by 1-butanol resulted in diminished PIP ( 2 ) in the plasma membrane and eliminated
EGF induced
calpain activation
Zadran et al., J Neurosci 2010
:
Remarkably, BDNF- and
EGF induced
calpain activation was preferentially localized in dendrites and dendritic spines of hippocampal neurons and was associated with actin polymerization, which was prevented by calpain inhibition
Ma et al., J Clin Invest 2011
(Disease Models, Animal...) :
Our data provide evidence that
calpain mediates
EGF- and PDGF induced collagen synthesis and proliferation of pulmonary artery smooth muscle cells via an intracrine TGF-ß1 pathway in pulmonary hypertension
Kawashima et al., Endocrinology 2012
:
The latter are controlled by
calpain activation downstream of the
EGF receptor activation of the Ca ( 2+ ) pathway and ERK1/2 pathways