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CAPN3 — PDCD6

Text-mined interactions from Literome

Rami et al., Brain Res 2000 (Brain Ischemia...) : We tested a potential role for calpain in the programmed cell death under ischemic conditions and found that calpain is ( 1 ) activated at a time preceding morphological changes, DNA fragmentation and death, ( 2 ) that calpain is translocated to the nucleus before DNA laddering, ( 3 ) pretreatment with caspase inhibitors and/or calpain inhibitors block not only the proteolytic actions of the enzyme, but also the cell death process itself in the CA1 subfield after transient global ischemia in a synergistic manner
Wales et al., Gene Ther 2008 (Parkinson Disease) : ICP10PK inhibits calpain dependent release of apoptosis inducing factor and programmed cell death in response to the toxin MPP+
Suryakumar et al., J Cardiovasc Pharmacol 2010 (Cardiomegaly...) : Because beta3 integrin contributes to cardioprotective signaling, these studies indicate that the loss of specific integrin function could be a key mechanism for calpain mediated programmed cell death of cardiomyocytes in PO myocardium
Dong et al., Cancer Res 2010 (Prostatic Neoplasms) : Combination therapy significantly elevated SSB level, ?-H2AX foci formation, and poly ( ADP-ribosylation ) of PARP-1, which were associated with ATP loss and induction of µ-calpain induced programmed cell death
Perez-Pinzon et al., J Cereb Blood Flow Metab 2012 (Nerve Degeneration) : Oxidative stress and Ca ( 2+ ) -activated calpain protease activities also promote apoptosis and other forms of programmed cell death , primarily through modification of proteins and lipids present at the outer membrane, causing release of proapoptotic mitochondrial proteins, which initiate caspase dependent and caspase independent forms of cell death