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CAPN5 — CDK5

Text-mined interactions from Literome

Lin et al., Cell Death Differ 2006 : Here we report that calpain mediated Cdk5/p25 activation accompanies non-neuronal as well as neuronal cell death, suggesting that the p35/calpain/p25/Cdk5 activation sequence is a general feature of cell death
Qu et al., Neuron 2007 (MPTP Poisoning...) : We reported previously that calpain mediated Cdk5 activation is critical for mitochondrial toxin induced dopaminergic death ... We propose a mechanistic model by which mitochondrial toxin leads to calpain mediated Cdk5 activation, reduced Prx2 activity, and decreased capacity to eliminate ROS
Wang et al., J Neurochem 2007 (AIDS Dementia Complex) : Taken together, our data suggest calpain activation of CDK5 , a pathway activated in HIV infected individuals, can mediate neuronal damage and death in a model of HIV induced neurotoxicity
Lebel et al., Neuropharmacology 2009 : We demonstrate, using pharmacological tools, that PKA activation causes increase of calcium levels, leading to cyclin dependent kinase 5 activation by calpain proteolysis of p35 to p25 and glycogen synthase kinase 3beta activation by its phosphorylation at tyrosine 216
Ye et al., J Biomed Biotechnol 2009 (Necrosis) : The kinase is typically activated by p25, derived from p35 by calpain mediated cleavage, but inhibition of calpain does not affect cell death or the activation of Cdk5
Cataldo et al., Mol Cell Biol 2013 : USP1 stability can be rescued upon forced expression of calpain activated Cdk5/p25 , previously reported as a cdh1 repressor