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CAPN8 — XIAP
Text-mined interactions from Literome
Kobayashi et al., J Biol Chem 2002
(Leukemia, Neutrophilic, Chronic) :
These observations suggest that
calpain mediated
XIAP degradation contributes to initiation of apoptosis in normal neutrophils and dysfunction of this regulatory pathway can lead to pathological neutrophil accumulation
Hwang et al., Int J Oncol 2003
:
Taken together, the apoptotic effects of NPPA may be related, in part to the caspase-3 activation, the down-regulation of
XIAP , and Bax cleavage
mediated by caspase dependent
calpain activation
Wootz et al., Exp Cell Res 2006
(Amyotrophic Lateral Sclerosis) :
Overexpression of
XIAP inhibited caspase-12 cleavage and
reduced calpain activity in the ALS mice