Gene interactions and pathways from curated databases and text-mining

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CASP10 — SHC1

Text-mined interactions from Literome

Hallé et al., Mol Cell Biol 2007 : Moreover, caspase-3 regulated PTP-PEST interactions with paxillin, leupaxin, Shc , and PSTPIP
John et al., Histol Histopathol 2007 (MAP Kinase Signaling System) : IL-18 lead to inhibition of collagen type II-deposition, decreased beta-integrin receptor and vinculin synthesis, SHC and MAPKinase activation, increased COX-2 synthesis and activation of caspase-3 in chondrocytes in a time- and dose dependent manner