Gene interactions and pathways from curated databases and text-mining

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CASP16 — PIK3R1

Text-mined interactions from Literome

Goswami et al., J Neurosci Res 2000 : Lowering cyclic AMP ( cAMP ) levels enhanced both caspase-3 activation and cell death induced by PI3K inhibitors, whereas a nonhydrolyzable cAMP analog ( Bt2cAMP ), lowered CPP32 and was protective
Lee et al., J Biol Chem 2001 : We also demonstrated that HBx inhibits caspase 3 activity and HBx down-regulation of caspase 3 activity was blocked by the PI3K inhibitor
Bernabé et al., Exp Cell Res 2001 (MAP Kinase Signaling System) : Thus, we propose that exposure to apoptotic concentrations of NO triggers ERK- and p38 dependent cytochrome c release, caspase 3 activation , and PI3K dependent Bcl-2 phosphorylation
Hideshima et al., Oncogene 2001 (MAP Kinase Signaling System...) : We demonstrate that Dex induced apoptosis in MM.1S cells is mediated by downstream activation of caspase-9 , with resultant caspase-3 cleavage ; and conversely, that IL-6 triggers activation of PI3-K and its association with SHP2, inactivates caspase-9, and protects against Dex induced apoptosis
King et al., Brain Res 2001 : MPP induced caspase-3 activation was increased by inhibition of PI3K , and decreased by stimulation of PI3K, indicative of anti-apoptotic signaling by the PI3K/Akt pathway ... Rotenone induced activation of caspase-3 was enhanced by inhibition of PI3K or increased GSK3beta activity, and was attenuated by inhibiting GSK3beta with lithium
Baudhuin et al., Mol Pharmacol 2002 : LPA/S1P induced Akt activation may be involved in cell survival, because LPA and S1P treatment in HEY ovarian cancer cells results in a decrease in paclitaxel induced caspase-3 activity in a PI3-K/MEK/p38 dependent manner
Yanagawa et al., Endocr Relat Cancer 2004 (Ascites...) : The anti-apoptotic effect of AMF has been described by other authors who have shown that the AMF over expressing cells were resistant to mitomycin-C induced apoptosis showing regression of Apaf-1 and caspase-9 dependent on PI3K and MAP kinase
Koh et al., Brain Res Mol Brain Res 2005 : To evaluate the protective effects of low concentration of DADS on oxidative stress injured nPC12 cells, the viability of the cells ( pretreated with DADS for 2 h vs. not pretreated ) was evaluated 24 h after exposure to 100 microM H2O2 for 30 min. Compared to the cells treated with 100 microM H2O2 only, pretreatment of the cells with 20 microM DADS before exposure to 100 microM H2O2 increased the viability and induced activation of PI3K and Akt, inactivation of GSK-3, and inhibition of cytochrome c release, caspase-3 activation , and PARP cleavage ... These results indicate that low concentration of DADS has neuroprotective effects by activating PI3K/Akt and by inhibiting GSK-3 activation, cytochrome c release, caspase-3 activation, and PARP cleavage, whereas high concentration is rather cytotoxic
Cruz et al., J Biol Chem 2007 (Inflammation) : In parallel, ATP mediated ROS dependent PI3K is required for activation of caspase-1 and secretion of IL-1beta and IL-18
Kozuma et al., Journal of thrombosis and haemostasis : JTH 2007 : We thus hypothesized that PI3 K inhibits the activation of caspase-3 and consequent cleavage of Bcl-xL
Zhao et al., Biochem Biophys Res Commun 2007 (Diabetes Mellitus...) : PI3K inhibitor, LY294002 attenuated ghrelin 's inhibitory effect on caspase-3 activity
Baki et al., J Neurosci 2008 (Alzheimer Disease...) : Familial Alzheimer disease ( FAD ) mutations suppress the ability of PS1 to promote PI3K/AKT signaling, prevent phosphorylation/inactivation of GSK-3 and promote activation of caspase-3
Kuijk et al., Blood 2008 (Mevalonate Kinase Deficiency) : HMG-CoA reductase inhibition induces IL-1beta release through Rac1/PI3K/PKB dependent caspase-1 activation ... IL-1beta release is mediated by caspase-1, and simvastatin treatment resulted in increased caspase-1 activity in a Rac1/PI3K dependent manner
Liu et al., Ann Hematol 2010 (Leukemia, Myeloid) : Inactivation of PI3k/Akt signaling pathway and activation of caspase-3 are involved in tanshinone I-induced apoptosis in myeloid leukemia cells in vitro
Xiang et al., Cell Biochem Funct 2011 : The inhibitory effect of ghrelin on caspase-3 activity was attenuated by inhibitors of ERK1/2 ( PD98059 ), PI3K/Akt ( LY294002 ) and growth hormone secretagogue receptor ( GHSR ) -1a ( D-Lys ( 3 ) -growth hormone releasing peptide-6 )
Lee et al., Apoptosis 2012 (Melanoma) : Our data reveal that celastrol inhibits growth and induces apoptosis in melanoma cells via the activation of ROS mediated caspase dependent and -independent pathways and the suppression of PI3K/AKT signaling
Martínez-Palacián et al., PloS one 2013 : Interestingly, both PI3K inhibition and/or knockdown itself resulted in caspase-3 activation and loss of viability in Met ( flx/flx ) oval cells, whereas no effect was observed in Met ( -/- ) oval cells