◀ Back to PIK3R1
CBL — PIK3R1
Pathways - manually collected, often from reviews:
-
BioCarta il-2 receptor beta chain in t cell activation:
CBL
→
PI3K complex (PIK3CA-PIK3R1)
(modification, activates)
-
KEGG Pathways in cancer:
Complex of CBL-CBLB-CBLC-CRK-CRKL
→
PIK3CA/PIK3CB/PIK3CD/PIK3CG/PIK3R1/PIK3R2/PIK3R3/PIK3R5
(protein-protein, activation)
-
KEGG Chronic myeloid leukemia:
Complex of CBL-CBLB-CBLC-CRK-CRKL
→
PIK3CA/PIK3CB/PIK3CD/PIK3CG/PIK3R1/PIK3R2/PIK3R3/PIK3R5
(protein-protein, activation)
-
NCI Pathway Database IL4-mediated signaling events:
CBL (CBL)
→
PI3K complex (PIK3CA-PIK3R1)
(modification, activates)
Ueno et al., Blood 1998*
Evidence: mutant phenotype, physical interaction
-
Reactome Reaction:
CBL
→
PIK3R1
(indirect_complex)
Dufour et al., Bone 2008, Odai et al., J Biol Chem 1995, Anderson et al., J Biol Chem 1997, Hunter et al., Mol Endocrinol 1997, Feshchenko et al., J Biol Chem 1998, Park et al., J Immunol 1998
-
Reactome Reaction:
CBL
→
PIK3R1
(reaction)
Odai et al., J Biol Chem 1995, Anderson et al., J Biol Chem 1997, Hunter et al., Mol Endocrinol 1997, Feshchenko et al., J Biol Chem 1998, Park et al., J Immunol 1998
Protein-Protein interactions - manually collected from original source literature:
Studies that report less than 10 interactions are marked with *
-
IRef Biogrid Interaction:
CBL
—
PIK3R1
(physical association, affinity chromatography technology)
Ueno et al., Blood 1998*
-
IRef Biogrid Interaction:
CBL
—
PIK3R1
(physical association, affinity chromatography technology)
Feshchenko et al., Oncogene 2004*
-
IRef Biogrid Interaction:
CBL
—
PIK3R1
(physical association, affinity chromatography technology)
Kassenbrock et al., J Biol Chem 2002*
-
IRef Biogrid Interaction:
CBL
—
PIK3R1
(physical association, affinity chromatography technology)
Fang et al., J Biol Chem 2001*
-
IRef Biogrid Interaction:
CBL
—
PIK3R1
(physical association, affinity chromatography technology)
Valiya Veettil et al., PLoS Pathog 2010*
-
IRef Biogrid Interaction:
CBL
—
PIK3R1
(physical association, affinity chromatography technology)
Gesbert et al., J Biol Chem 1998*
-
IRef Biogrid Interaction:
CBL
—
PIK3R1
(physical association, affinity chromatography technology)
Zhang et al., Biochem Biophys Res Commun 1999*
-
IRef Biogrid Interaction:
CBL
—
PIK3R1
(direct interaction, enzymatic study)
Matsuo et al., FEBS Lett 1996*
-
IRef Biogrid Interaction:
CBL
—
PIK3R1
(physical association, affinity chromatography technology)
Matsuo et al., FEBS Lett 1996*
-
IRef Biogrid Interaction:
CBL
—
PIK3R1
(physical association, affinity chromatography technology)
Miao et al., Biochem Biophys Res Commun 2002*
-
IRef Biogrid Interaction:
CBL
—
PIK3R1
(physical association, affinity chromatography technology)
Saci et al., Biochem J 2000*
-
IRef Biogrid Interaction:
CBL
—
PIK3R1
(physical association, affinity chromatography technology)
Wang et al., J Cell Biochem 1999
-
IRef Biogrid Interaction:
CBL
—
PIK3R1
(physical association, affinity chromatography technology)
Meisner et al., Mol Cell Biol 1995*
-
IRef Biogrid Interaction:
CBL
—
PIK3R1
(physical association, affinity chromatography technology)
Hartley et al., J Biol Chem 1996*
-
IRef Biogrid Interaction:
CBL
—
PIK3R1
(direct interaction, enzymatic study)
Jackson et al., Oncogene 2000*
-
IRef Biogrid Interaction:
CBL
—
PIK3R1
(physical association, affinity chromatography technology)
Beckwith et al., Blood 1996*
-
IRef Biogrid Interaction:
CBL
—
PIK3R1
(physical association, affinity chromatography technology)
Song et al., Cell Signal 2010*
-
IRef Biogrid Interaction:
CBL
—
PIK3R1
(direct interaction, pull down)
Saci et al., J Biol Chem 1999*
-
IRef Biogrid Interaction:
CBL
—
PIK3R1
(physical association, affinity chromatography technology)
Saci et al., J Biol Chem 1999*
-
IRef Biogrid Interaction:
CBL
—
PIK3R1
(physical association, affinity chromatography technology)
Finkelstein et al., Biochem J 2000*
-
IRef Biogrid Interaction:
CBL
—
PIK3R1
(direct interaction, pull down)
Hunter et al., Mol Endocrinol 1997
-
IRef Biogrid Interaction:
CBL
—
PIK3R1
(physical association, affinity chromatography technology)
Ren et al., Exp Hematol 2005*
-
IRef Biogrid Interaction:
CBL
—
PIK3R1
(physical association, affinity chromatography technology)
Hunter et al., Mol Endocrinol 1997
-
IRef Biogrid Interaction:
CBL
—
PIK3R1
(direct interaction, pull down)
Ren et al., Mol Cell Biol 2005*
-
IRef Biogrid Interaction:
CBL
—
PIK3R1
(physical association, affinity chromatography technology)
van Leeuwen et al., J Biol Chem 1999*
-
IRef Biogrid Interaction:
CBL
—
PIK3R1
(physical association, affinity chromatography technology)
Swaminathan et al., Oncogene 2007*
-
IRef Biogrid Interaction:
CBL
—
PIK3R1
(physical association, affinity chromatography technology)
Jain et al., Oncogene 1997*
-
IRef Biogrid Interaction:
CBL
—
PIK3R1
(direct interaction, pull down)
Jain et al., Oncogene 1997*
-
IRef Biogrid Interaction:
CBL
—
PIK3R1
(direct interaction, pull down)
Ren et al., Exp Hematol 2005*
-
IRef Biogrid Interaction:
CBL
—
PIK3R1
(physical association, affinity chromatography technology)
Liu et al., J Biol Chem 1997*
-
IRef Biogrid Interaction:
CBL
—
PIK3R1
(physical association, affinity chromatography technology)
Alcázar et al., Blood 2009*
-
IRef Biogrid Interaction:
CBL
—
PIK3R1
(physical association, affinity chromatography technology)
Lottin-Divoux et al., Cell Signal 2006*
-
IRef Biogrid Interaction:
CBL
—
PIK3R1
(direct interaction, pull down)
Matsuo et al., FEBS Lett 1996*
-
IRef Biogrid Interaction:
CBL
—
PIK3R1
(physical association, affinity chromatography technology)
Brehme et al., Proc Natl Acad Sci U S A 2009
-
IRef Biogrid Interaction:
CBL
—
PIK3R1
(physical association, affinity chromatography technology)
Panchamoorthy et al., J Biol Chem 1996
-
IRef Biogrid Interaction:
CBL
—
PIK3R1
(physical association, affinity chromatography technology)
Kitanaka et al., Blood 1996*
-
IRef Biogrid Interaction:
CBL
—
PIK3R1
(physical association, affinity chromatography technology)
Liu et al., J Biol Chem 1997*
-
IRef Biogrid Interaction:
CBL
—
PIK3R1
(direct interaction, far western blotting)
Grossmann et al., FEBS Lett 2004
-
IRef Biogrid Interaction:
CBL
—
PIK3R1
(physical association, affinity chromatography technology)
Chernock et al., Blood 2001
-
IRef Biogrid Interaction:
CBL
—
PIK3R1
(direct interaction, pull down)
Fukazawa et al., J Biol Chem 1995*
-
IRef Biogrid Interaction:
CBL
—
PIK3R1
(physical association, affinity chromatography technology)
Fukazawa et al., J Biol Chem 1995*
-
IRef Biogrid Interaction:
CBL
—
PIK3R1
(physical association, affinity chromatography technology)
Dufour et al., Bone 2008
-
IRef Biogrid Interaction:
CBL
—
PIK3R1
(direct interaction, enzymatic study)
Miao et al., Biochem Biophys Res Commun 2002*
-
IRef Biogrid Interaction:
CBL
—
PIK3R1
(physical association, affinity chromatography technology)
Gelkop et al., J Biol Chem 2001*
-
IRef Biogrid Interaction:
CBL
—
PIK3R1
(direct interaction, pull down)
Hakak et al., Oncogene 2000*
-
IRef Biogrid Interaction:
CBL
—
PIK3R1
(physical association, affinity chromatography technology)
Hakak et al., Oncogene 2000*
-
IRef Biogrid Interaction:
CBL
—
PIK3R1
(physical association, affinity chromatography technology)
Cerboni et al., Eur J Immunol 1998*
-
IRef Biogrid Interaction:
CBL
—
PIK3R1
(physical association, affinity chromatography technology)
Liu et al., J Immunol 1999*
-
IRef Biogrid Interaction:
CBL
—
PIK3R1
(direct interaction, pull down)
Momose et al., J Immunol 2003*
-
IRef Biogrid Interaction:
CBL
—
PIK3R1
(physical association, affinity chromatography technology)
Fukazawa et al., J Biol Chem 1996
-
MIPS CORUM CIN85 complex (CIN85, CRK, BCAR1, CBL, PIK3R1, GRB2, SOS1):
CIN85 complex (CIN85, CRK, BCAR1, CBL, PIK3R1, GRB2, SOS1) complex (BCAR1-CBL-CRK-GRB2-PIK3R1-SH3KBP1-SOS1)
Watanabe et al., Biochem Biophys Res Commun 2000
-
MIPS CORUM LAT-PLC-gamma-1-p85-GRB2-CBL-VAV-SLP-76 signaling complex, C305 activated:
LAT-PLC-gamma-1-p85-GRB2-CBL-VAV-SLP-76 signaling complex, C305 activated complex (CBL-GRB2-LAT-LCP2-PIK3R1-PLCG1-VAV1)
Zhang et al., Cell 1998
-
IRef Corum Interaction:
Complex of LCP2-GRB2-PIK3R1-CBL-LAT-PLCG1-VAV1
(association, coimmunoprecipitation)
Zhang et al., Cell 1998
-
IRef Corum Interaction:
Complex of SH3KBP1-SOS1-PIK3R1-GRB2-CBL-BCAR1-CRK
(association, coimmunoprecipitation)
Watanabe et al., Biochem Biophys Res Commun 2000
-
IRef Hprd Interaction:
CBL
—
PIK3R1
(in vitro)
Lin et al., Int Immunol 2001*, Ren et al., Exp Hematol 2005*, Fukazawa et al., J Biol Chem 1995*, Panchamoorthy et al., J Biol Chem 1996, Fukazawa et al., J Biol Chem 1996, Bonita et al., Mol Cell Biol 1997*
-
IRef Hprd Interaction:
CBL
—
PIK3R1
(in vivo)
Lin et al., Int Immunol 2001*, Ren et al., Exp Hematol 2005*, Fukazawa et al., J Biol Chem 1995*, Panchamoorthy et al., J Biol Chem 1996, Fukazawa et al., J Biol Chem 1996, Bonita et al., Mol Cell Biol 1997*
-
IRef Hprd Interaction:
Complex of CBL-SYK-PIK3R1-PIK3R1-SYK-CBL-SYK-CBL-PIK3R1
(in vivo)
Grossmann et al., FEBS Lett 2004
-
IRef Hprd Interaction:
Complex of GRB2-CBL-PIK3R1-CBL-GRB2-PIK3R1-PIK3R1-GRB2-CBL
(in vivo)
Fukazawa et al., J Biol Chem 1995*
-
IRef Hprd Interaction:
Complex of CBL-PIK3R1-CBL-PIK3R1-PIK3R1-CBL
(in vivo)
Grossmann et al., FEBS Lett 2004
-
IRef Hprd Interaction:
Complex of 26 proteins
(in vivo)
Zhang et al., Cell 1998
-
IRef Intact Interaction:
CBL
—
PIK3R1
(physical association, anti bait coimmunoprecipitation)
Fukazawa et al., J Biol Chem 1995*
-
IRef Intact Interaction:
CBL
—
PIK3R1
(physical association, coimmunoprecipitation)
Fukazawa et al., J Biol Chem 1996
-
IRef Intact Interaction:
CBL
—
PIK3R1
(physical association, pull down)
Hunter et al., J Biol Chem 1999*
-
IRef Intact Interaction:
CBL
—
PIK3R1
(physical association, two hybrid)
Dombrosky-Ferlan et al., Oncogene 1997*
-
IRef Intact Interaction:
CBL
—
PIK3R1
(association, experimental interaction detection)
Grossmann et al., FEBS Lett 2004
-
IRef Intact Interaction:
CBL
—
PIK3R1
(physical association, anti bait coimmunoprecipitation)
Standaert et al., Biochemistry 2004*
-
IRef Intact Interaction:
CBL
—
PIK3R1
(association, far western blotting)
Grossmann et al., FEBS Lett 2004
-
IRef Intact Interaction:
CBL
—
PIK3R1
(physical association, pull down)
Ren et al., Exp Hematol 2005*
-
IRef Intact Interaction:
CBL
—
PIK3R1
(physical association, anti bait coimmunoprecipitation)
Hartman et al., Exp Hematol 2006*
-
IRef Intact Interaction:
CBL
—
PIK3R1
(physical association, coimmunoprecipitation)
Panchamoorthy et al., J Biol Chem 1996
-
IRef Intact Interaction:
Complex of UBASH3B-SHC1-PCCB-MCCC2-GRB2-INPPL1-CBL-PIK3R1-PIK3R2
(association, tandem affinity purification)
Brehme et al., Proc Natl Acad Sci U S A 2009
-
IRef Intact Interaction:
Complex of 28 proteins
(association, tandem affinity purification)
Brehme et al., Proc Natl Acad Sci U S A 2009
-
IRef Intact Interaction:
Complex of 29 proteins
(association, tandem affinity purification)
Brehme et al., Proc Natl Acad Sci U S A 2009
-
IRef Intact Interaction:
Complex of 37 proteins
(association, tandem affinity purification)
Brehme et al., Proc Natl Acad Sci U S A 2009
-
IRef Intact Interaction:
Complex of 17 proteins
(association, anti bait coimmunoprecipitation)
Brehme et al., Proc Natl Acad Sci U S A 2009
-
IRef Intact Interaction:
Complex of 12 proteins
(association, tandem affinity purification)
Brehme et al., Proc Natl Acad Sci U S A 2009
-
IRef Ophid Interaction:
CBL
—
PIK3R1
(aggregation, interologs mapping)
Brown et al., Bioinformatics 2005
Text-mined interactions from Literome
Take et al., Biochem Biophys Res Commun 2000
:
Our results suggest that
CIN85 may
play a specific role in the
EGF receptor mediated signaling cascade via its interaction with c-Cbl
Fang et al., Nat Immunol 2001
:
Proteolysis independent
regulation of
PI3K by
Cbl-b mediated ubiquitination in T cells
Petrelli et al., Nature 2002
:
Cbl, in turn, binds and ubiquitinates activated
HGF receptor , and by recruiting the
endophilin-CIN85 complex , it
regulates receptor internalization
Qin et al., Biochemistry 2003
:
Under our conditions, hydrogen peroxide induced
PI3K and Akt activation was
independent of Lyn, Syk,
Cbl , BCAP, or Ras when each was eliminated individually either by mutation or by a specific inhibitor
Kowanetz et al., J Biol Chem 2003
:
Identification of a novel proline-arginine motif involved in
CIN85 dependent clustering of Cbl and down-regulation of
epidermal growth factor receptors
Guenou et al., Am J Pathol 2006
(Acrocephalosyndactylia) :
Down-regulation of ubiquitin ligase
Cbl induced by twist haploinsufficiency in Saethre-Chotzen syndrome
results in increased
PI3K/Akt signaling and osteoblast proliferation ... This provides genetic and biochemical evidence for a role for
Cbl mediated
PI3K signaling in the altered osteoblast phenotype induced by Twist haploinsufficiency in SCS
Peruzzi et al., J Immunol 2007
(Calcium Signaling) :
We found that
CIN85 overexpression
inhibits the FcepsilonRI induced tyrosine phosphorylation of
phospholipase Cgamma , thus altering calcium mobilization ... Altogether, our findings support a new
role for
CIN85 in regulating
Syk protein levels in RBL-2H3 cells through the activation of the ubiquitin-proteasome pathway and provide a mechanism for this regulation involving c-Cbl ligase activity
Dufour et al., Bone 2008
:
Biochemical and molecular analyses revealed that the attenuated
PI3K signaling induced by FGFR2 activation is
due to increased
Cbl-PI3K molecular interaction mediated by the Cbl Y731 residue, which results in increased PI3K ubiquitination and proteasome degradation
Wakasaki et al., Neoplasia (New York, N.Y.) 2010
(Carcinoma, Squamous Cell...) :
Little is known, however, about a
role of
CIN85 in
EGFR signaling as well as its relevance to tumor development and progression of HNSCC
Yingchun et al., Braz J Med Biol Res 2011
:
In the present study, we evaluated whether E3 ubiquitin ligase
Cbl-b , a negative
regulator of
PI3K activation, is involved in the action of ATO
Marois et al., J Biol Chem 2011
:
Silencing the expression of
CIN85 by siRNA in dibutyryl cyclic AMP differentiated PLB 985 cells
prevented Fc?RIIa degradation and increased IgG mediated phagocytosis
Sévère et al., J Biol Chem 2011
:
Analysis of molecular mechanisms revealed that the
Cbl mutant
increased PDGF receptor a and FGF receptor 2 but not EGF receptor expression in hMSCs, resulting in increased ERK1/2 and
PI3K signaling
Tossidou et al., Mol Cell Biol 2012
:
Our results indicate a novel
role for
CD2AP in regulating posttranslational modification of
CIN85
Guo et al., Cell reports 2012
:
Here, we report that
Cbl-b does not
inhibit PI3K but rather suppresses TCR/CD28 induced inactivation of Pten
Samoylenko et al., Carcinogenesis 2012
(Adenocarcinoma...) :
Thereby, Ruk ( l )
/CIN85 led to a more rapid and prolonged epidermal growth factor dependent activation of
Src , Akt and ERK1/2 and treatment with the Src inhibitor PP2 and the PI3K inhibitor LY294002 abolished the Ruk ( l ) /CIN85 dependent changes in cell motility ... Thereby, Ruk ( l )
/CIN85 led to a more rapid and prolonged epidermal growth factor dependent activation of Src, Akt and
ERK1/2 and treatment with the Src inhibitor PP2 and the PI3K inhibitor LY294002 abolished the Ruk ( l ) /CIN85 dependent changes in cell motility ... Thereby, Ruk ( l )
/CIN85 led to a more rapid and prolonged epidermal growth factor dependent activation of Src,
Akt and ERK1/2 and treatment with the Src inhibitor PP2 and the PI3K inhibitor LY294002 abolished the Ruk ( l ) /CIN85 dependent changes in cell motility
Schroeder et al., Mol Biol Cell 2012
:
In this study we show that
EGFR activation
leads to a pronounced src mediated tyrosine phosphorylation of
CIN85 that subsequently influences EGFR ubiquitination
Bior et al., FEBS Lett 2013
:
Dab1 stabilizes its interaction with
Cin85 by suppressing Cin85 phosphorylation at serine 587 ... Furthermore a
Cin85 Ser587 phosphomimetic
disrupts the
Dab1-Cin85 complex without affecting the Cin85-CapZ complex
Fuchigami et al., Genes Cells 2013
:
We reported previously that
Cdk5-p35 phosphorylates Dab1 at Ser400 and Ser491 and the phosphorylation
regulates its binding to
CIN85 , which is an SH3 containing multiadaptor protein involved in endocytic downregulation of receptor-tyrosine kinases ... We reported previously that
Cdk5-p35 phosphorylates Dab1 at Ser400 and Ser491 and the phosphorylation
regulates its binding to
CIN85 , which is an SH3 containing multiadaptor protein involved in endocytic downregulation of receptor-tyrosine kinases ... We reported previously that Cdk5-p35 phosphorylates
Dab1 at Ser400 and Ser491 and the phosphorylation
regulates its binding to
CIN85 , which is an SH3 containing multiadaptor protein involved in endocytic downregulation of receptor-tyrosine kinases
Saci et al., J Biol Chem 1999
:
Our results suggest that
Cbl is
involved in platelet signal transduction by the recruitment of PI 3-K to the FcgammaRIIa pathway, possibly by increasing
PI 3-K activity