Gene interactions and pathways from curated databases and text-mining

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CCDC88A — PIK3R1

Text-mined interactions from Literome

Myou et al., J Immunol 2003 (MAP Kinase Signaling System) : We find that PI3K is required for gIV-PLA(2) activation and hydrolytic production of AA in activated eosinophils ... Our data suggest that this essential PI3K independently activates gIV-PLA(2) through a pathway that does not involve MAPK
Lin et al., Science signaling 2011 : These phosphorylation events enabled direct binding of GIV to the amino- and carboxyl-terminal Src homology 2 domains of p85a, a regulatory subunit of PI3K ; stabilized receptor association with PI3K ; and enhanced PI3K activity at the plasma membrane to trigger cell migration