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CCL2 — CCL3
Text-mined interactions from Literome
Wada et al., Kidney Int 1999
(Glomerulonephritis...) :
These observations suggest that locally produced
MIP-1alpha may be involved in the development of cellular crescents in the acute phase via CCR5 and that
MCP-1 may be
involved mainly in the development of interstitial lesions in the chronic phase when fibrocellular/fibrous crescents are present, possibly through Mphi recruitment and activation
Andjelkovic et al., J Neurochem 2000
:
Specifically, labeled
MCP-1 binding to isolated brain microvessels was
inhibited by unlabeled MCP-1 and MCP-3, the latter another CCR2 ligand, but not by
MIP-1alpha
Crane et al., Invest Ophthalmol Vis Sci 2001
(Autoimmune Diseases...) :
MCP-1 and RANTES were
detected on CD3 positive cells and on some ED1 positive cells, whereas
MIP-1alpha was also associated with vessels and areas of exudate
Harandi et al., Am J Reprod Immunol 2001
(Herpes Genitalis) :
HSV-2 infection did not
induce any measurable levels of
MIP-1alpha , whereas high levels of RANTES and
MCP-1 were detected in unvaccinated animals at 48 hr post challenge
Solomon et al., Xenotransplantation 2003
:
The impeded migration of leukocytes into xenografts in CCR2-/- hosts was associated with delayed intragraft expression of MCP-1 and RANTES mRNA ; absence of
MCP-1/CCR2 mediated signaling
led to enhanced intragraft expression of MCP-1,
MIP-1alpha and MIP-1beta mRNA
Yamamoto et al., Toxicol Appl Pharmacol 2006
(Pneumonia) :
LTA produced a dose related increase in early pulmonary inflammation, which was characterized by ( 1 ) influx of polymorphonuclear neutrophils ( PMNs ) and ( 2 ) induction of interleukin (IL)-6, tumor necrosis factor (TNF)-alpha, macrophage inflammatory protein
(MIP)-1alpha/CCL3 , but no
effect on monocyte chemoattractant protein
(MCP)-1/CCL2 at 24 h after instillation
Wang et al., Zhongguo Shi Yan Xue Ye Xue Za Zhi 2006
(Leukemia, Myelogenous, Chronic, BCR-ABL Positive) :
It is concluded that P210 ( bcr/abl ) fusion protein inhibits the expression of
MIP-1alpha and CCR-1 in chronic myeloid leukemia cells, but does not
inhibit MCP-1 and CCR-2 mRNA expressions in these leukemia cells
Pattarini et al., Neuroscience 2007
(Disease Models, Animal...) :
Using Mcp-1/Ccl2 knockout mice backcrossed onto a C57BL/6J background we found that MPTP stimulated Mip-1alpha/Ccl3 and Mip-1beta/Ccl4 mRNA expression was significantly lower in the knockout mice ; suggesting that
Mcp-1/Ccl2 contributes to MPTP enhanced expression of
Mip-1alpha/Ccl3 and Mip-1beta/Ccl4
Sharma et al., Am J Physiol Lung Cell Mol Physiol 2007
(Inflammation...) :
H/R ( 3 h/1 h ) significantly
induced KC,
MCP-1 , macrophage inflammatory protein-2 ( MIP-2 ), RANTES, and IL-6 ( but not TNF-alpha ) by MLE-12 cells, whereas H/R induced TNF-alpha, MCP-1, RANTES,
MIP-1alpha , and MIP-2 ( but not KC ) by RAW264.7 cells
Stuart et al., Frontiers in bioscience : a journal and virtual library 2008
(Disease Progression...) :
Previous studies addressing the role of these chemokines during primary herpetic stromal keratitis ( HSK ), have suggested that
CCL2 is involved in reducing corneal disease and that
CCL3 is
involved in promoting this disease
Luo et al., J Immunol 1996
:
In addition, TCA3,
MIP-1 alpha , and
MCP-1 increase vascular smooth muscle cell adhesiveness to type III collagen
Lukacs et al., J Immunol 1997
(Hypersensitivity...) :
Depletion of
MCP-1 significantly
reduced the airway hyperreactivity to near control levels, whereas depletion of
MIP-1alpha or RANTES did not affect the intensity of airway hyperreactivity
Huffnagle et al., J Immunol 1997
(Cryptococcosis) :
Neutralization of MIP-1alpha did not significantly decrease the levels of monocyte chemotactic protein-1 (MCP-1) ; however, neutralization of MCP-1 significantly decreased MIP-1alpha levels, demonstrating that induction of
MIP-1alpha was largely
dependent on
MCP-1 production
Bussfeld et al., Cell Immunol 1998
:
In comparison with fully infectious influenza A, 56 degrees C-inactivated virus
induced a strong production of
MCP-1 , MIP-1 alpha, and IP-10, while the release of
MIP-1 alpha and IP-10 was substantially lower after exposure to UV-inactivated virus