◀ Back to PTEN

CCND1 — PTEN

Text-mined interactions from Literome

Radu et al., Mol Cell Biol 2003 : Expression of wild-type PTEN but not of mutant forms unable to dephosphorylate phosphoinositides reduced the expression of cyclin D1 ... PTEN expression also prevented cyclin D1 from localizing to the nucleus during the G ( 1 ) - to S-phase cell cycle transition ... Constitutively active Akt/PKB kinase counteracted the effect of PTEN on cyclin D1 translocation
Waite et al., Hum Mol Genet 2005 : Active PTEN results in decreased phosphorylation of Akt and MAPK, the up-regulation of p27 and down-regulation of cyclin D1 protein levels resulting in decreased proliferation and an increase in apoptosis
Chung et al., Hum Mol Genet 2006 : We have shown that PTEN localizes to the nucleus coincident with the G0-G1 phases of the cell cycle and that compartmentalization may regulate cell cycle progression dependent upon the down-regulation of cyclin D1
Jonason et al., Cell cycle (Georgetown, Tex.) 2007 : Here, we show that PTEN negatively regulates expression of cyclin D1 and that cyclin D1 plays a unique role in p27 proteolysis
Kang et al., Amino Acids 2011 (Carcinoma, Hepatocellular...) : Expression of ESM-1 siRNA decreased cell survival through the inhibition of NF-?B pathway and induced cell cycle arrest by PTEN induction resulting in the inhibition of cyclin D1 in SK-Hep1 cells