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CCND2 — PIK3R1
Text-mined interactions from Literome
Banerji et al., Oncogene 2001
(Lymphoma, B-Cell...) :
Inhibition of
PI3-K signalling by LY294002
down-regulated cyclin D2 and up-regulated p27 ( Kip1 ) expression at both protein and RNA levels, mimicking the effects of BCR-stimulation
Glassford et al., Oncogene 2003
(Calcium Signaling...) :
These findings are further confirmed by studies showing that specific pharmacological inhibitors of Btk ( LFM-A13 ),
PI3-K ( LY294002 and Wortmannin ) and PLCgamma ( U73122 ) also
block cyclin D2 expression and S phase entry following BCR stimulation, as well as triggering apoptosis
Glassford et al., Eur J Immunol 2005
:
The inhibitors of PI3K activity, LY294002 and Wortmannin, also abrogate cyclin D2 induction by BCR cross linking, confirming that the class IA
PI3K is
necessary for
cyclin D2 induction in response to BCR stimulation ... Furthermore, using both p85alpha-null and p110delta-null B cells and inhibitors of PI3K, this study demonstrates for the first time, that BCR cross linking induces cyclin D2 mRNA expression via transcriptional activation of the cyclin D2 promoter and that this transcriptional activation of
cyclin D2 requires
PI3K activity