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CCNH — TP53
Protein-Protein interactions - manually collected from original source literature:
Studies that report less than 10 interactions are marked with *
Text-mined interactions from Literome
Ababneh et al., Biochem Biophys Res Commun 2001
:
Our present study provides evidence that
p53 might
regulate cell-cycle checkpoints not only on the transcriptional level but also by binding to the cell-cycle regulating kinase
p34 ( cdc2 )
Jaiswal et al., Int J Oncol 2001
(Colonic Neoplasms) :
However, with cyclin dependent kinase ( Cdk2 ) and TFIIH complex associated kinase
CAK , the phosphorylation of
p53 was
increased at later time points ( 25 h )
Yamamoto et al., Exp Cell Res 1994
:
Our data support the idea that tumor suppressors modulate the expression of cell cycle-regulatory genes : RB regulates
p34cdc2 expression and
p53 regulates cyclin A expression
Yasui et al., Int J Cancer 1993
(Colonic Neoplasms...) :
These findings suggest that the increased
p34cdc2 kinase activity might
cause the development and proliferation of gastric and colonic carcinomas, partly through abnormal
p53 accumulation