Gene interactions and pathways from curated databases and text-mining

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CCNH — TP53

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

Text-mined interactions from Literome

Ababneh et al., Biochem Biophys Res Commun 2001 : Our present study provides evidence that p53 might regulate cell-cycle checkpoints not only on the transcriptional level but also by binding to the cell-cycle regulating kinase p34 ( cdc2 )
Jaiswal et al., Int J Oncol 2001 (Colonic Neoplasms) : However, with cyclin dependent kinase ( Cdk2 ) and TFIIH complex associated kinase CAK , the phosphorylation of p53 was increased at later time points ( 25 h )
Yamamoto et al., Exp Cell Res 1994 : Our data support the idea that tumor suppressors modulate the expression of cell cycle-regulatory genes : RB regulates p34cdc2 expression and p53 regulates cyclin A expression
Yasui et al., Int J Cancer 1993 (Colonic Neoplasms...) : These findings suggest that the increased p34cdc2 kinase activity might cause the development and proliferation of gastric and colonic carcinomas, partly through abnormal p53 accumulation