Gene interactions and pathways from curated databases and text-mining

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CD2 — PIK3R1

Pathways - manually collected, often from reviews:

Text-mined interactions from Literome

Shimizu et al., J Cell Biol 1995 (Leukemia, Promyelocytic, Acute) : A role for PI 3-K in CD2 mediated increases in beta 1 integrin function is suggested by : ( a ) the ability of the PI 3-K inhibitor wortmannin to completely inhibit CD2 induced increases in beta 1 integrin activity ; ( b ) the association of PI 3-K with CD2; and (c) induced PI 3-K activity upon CD2 stimulation
Kivens et al., Mol Cell Biol 1998 : Mutation of the proline residues in the K-G-P-P-L-P motif to alanines prevented CD2 mediated activation of integrin function and PI 3-K activity but not mitogen activated protein ( MAP ) kinase activity