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CD27 — CD4

Text-mined interactions from Literome

Xiao et al., J Immunol 2008 : We have examined whether CD4 ( + ) T cells require CD27 to deliver this help, in a model of intranasal OVA protein immunization ... CD27 deficiency reduced the capacity of CD4 ( + ) T cells to support Ag-specific CD8 ( + ) T cell accumulation at the tissue site after primary and secondary immunization ... CD27 dependent CD4 ( + ) T cell help for the memory CD8 ( + ) T cell response was delivered during priming
Hashimoto-Okada et al., Int Immunol 2009 : The CD70-CD27 interaction during the stimulation with dendritic cells promotes naive CD4 ( + ) T cells to develop into T cells producing a broad array of immunostimulatory cytokines in humans ... However, it has not been extensively examined whether human primary DCs express CD70 and whether the CD70-CD27 interaction promotes naive CD4 ( + ) T cells to acquire the ability to produce effector cytokines during the DC-T cell interaction in humans
Yonkers et al., J Infect Dis 2011 (Hepatitis C, Chronic) : Reduced naive CD4 T cell numbers and impaired induction of CD27 in response to T cell receptor stimulation reflect a state of immune activation in chronic hepatitis C virus infection
Claus et al., Cancer Res 2012 (Neoplasms, Experimental) : CD27 signaling reduced apoptosis of Tregs in vivo and induced CD4 ( + ) effector T cells ( Teffs ) to produce interleukin-2, a key survival factor for Tregs