Gene interactions and pathways from curated databases and text-mining

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CD28 — PIK3R1

Pathways - manually collected, often from reviews:

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

Text-mined interactions from Literome

Phu et al., J Leukoc Biol 2001 : These results support the conclusion that PI3-K activation is involved in T-cell receptor, CD28 , and IL-2 receptor signaling of CD8 ( + ) T cells
Bahlis et al., Blood 2007 (Multiple Myeloma) : We have found that direct activation of myeloma cell CD28 by anti-CD28 mAb alone induces activation of PI3K and NFkappaB, suppresses MM cell proliferation, and protects against serum starvation and dexamethasone ( dex ) -induced cell death
Nurieva et al., J Immunol 2007 : We found that CD28 and ICOS regulate sustained PI3K activity in primary T cells, which is required for NFATc1 up-regulation
Garçon et al., Blood 2008 : CD28 provides T-cell costimulation and enhances PI3K activity at the immune synapse independently of its capacity to interact with the p85/p110 heterodimer
Gogishvili et al., Eur J Immunol 2008 : In p110delta ( D910A/D910A ) transgenic T cells, which are defective in PI3K activation following CD28 ligation, proliferation was comparable to that in wild-type cells
Alcázar et al., Blood 2009 : Moreover, deletion of p85beta impaired CD28 induced intracellular events, including c-CBL and CBL-b down-regulation as well as PI3K pathway activation
Gigoux et al., Proc Natl Acad Sci U S A 2009 : Although it is known that CD28 mediated PI3K activation is dispensable for GC reaction, the role of ICOS-driven PI3K signaling has not been defined
Muscolini et al., J Immunol 2013 : Hence, PIP2 is a crucial substrate in driving the PI3K downstream signaling pathways, and PIP2 turnover may be an essential regulatory step to ensure the activation of PI3K following CD28 engagement
Truitt et al., J Immunol 1995 (Second Messenger Systems) : Stimulation of CD28 induces its association with phosphatidylinositol 3'-kinase (PI3-K), raising the possibility that PI3-K plays a critical role in CD28 signaling
Lu et al., Eur J Immunol 1995 : Wortmannin added to cell cultures partially inhibits CD28 induced tyrosine phosphorylation of the putative p110 catalytic subunit of PI3-K, but does not block CD28 induced association of the p85 PI3-K regulatory subunit with the CD28 receptor
Ghiotto-Ragueneau et al., Eur J Immunol 1996 : We demonstrate in this report that both CD28-B7.1 and CD28-B7.2 interactions induce the association of PI3-K to CD28 in the CD4 subpopulation, whereas it was barely detectable in CD8 cells
Lu et al., Eur J Immunol 1996 (Leukemia) : Engagement of CD28 caused the rapid receptor association and activation of PI3-K but did not activate phospholipase C gamma ... CD28 induced tyrosine phosphorylation and PI3-K activation was independent of p56lck protein tyrosine kinase ( PTK ) activity ( previously reported to be associated with CD28 ) and was insensitive to inhibition by the PTK inhibitor herbimycin A ... Two structurally and mechanistically dissimilar inhibitors of PI3-K, wortmannin and 2- ( 4-morpholinyl ) -8-phenyl-4H-1-benzopyran-4-one ( LY294002 ) also failed to block CD28 dependent tyrosine phosphorylation events or the association of PI3-K with the CD28 receptor ... Although herbimycin A did not significantly block the observed CD28 dependent tyrosine phosphorylation or PI3-K activation, herbimycin did block CD28 dependent cytotoxicity in a dose dependent manner ... These data support a role for PI3-K activation in the CD28 dependent initiation of cytotoxic effector function and suggest that a herbimycin sensitive step ( s ) is either CD28 independent, resides within a PI3-K independent CD28 signaling pathway, or is downstream of CD28 dependent PI3-K activation
Lu et al., J Immunol 1998 : Phosphatidylinositol 3-kinase is required for CD28 but not CD3 regulation of the TEC family tyrosine kinase EMT/ITK/TSK : functional and physical interaction of EMT with phosphatidylinositol 3-kinase ... CD28 induced association of EMT with PI3K also requires functional expression of LCK