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CD38 — TNF
Text-mined interactions from Literome
Barata et al., Endocrinology 2004
:
Furthermore, we investigated
TNFalpha regulation of oxytocin induced [ Ca2+ ] i transients,
CD38 cyclase activity, and CD38 expression in human myometrial cells ... Similarly,
CD38 mRNA levels, CD38 expression, and cyclase activity were
increased by
TNFalpha , thus increasing cADPR levels
Tliba et al., Mol Pharmacol 2004
:
In the present study, we investigated the major signaling pathways by which
tumor necrosis factor-alpha (TNFalpha) induces
CD38 expression and its role in regulating gene expression in human ASM cells ... Using flow cytometry analyses,
TNFalpha enhanced
CD38 expression in a manner that was time- ( 0-24 h ), concentration- ( 0.1-40 ng/ml ), and protein synthesis- ( cycloheximide blockade ) dependent ... Inhibition of the Janus activated kinase/signal transducer and activator of transcription pathways using the soluble inhibitor 2- ( 1,1-dimethylethyl ) -9-fluoro-3,6-dihydro-7H-benz- [ h ] imidaz [ 4,5-f ] isoquinolin-7-one ( DBI ) or with neutralizing antibody against interferon beta (IFNbeta) completely abrogated
TNFalpha induced
CD38 expression at both protein and mRNA levels
Thompson et al., Am J Physiol Endocrinol Metab 2004
:
First, we observed that
TNF-alpha increased oxytocin induced Ca ( 2+ ) transients and
CD38 expression in human myometrial cells
Kang et al., FASEB J 2006
:
Transcriptional
regulation of
CD38 expression by
tumor necrosis factor-alpha in human airway smooth muscle cells : role of NF-kappaB and sensitivity to glucocorticoids ... In human airway smooth muscle ( HASM ) cells, the expression and function of
CD38 are
augmented by the inflammatory cytokine
tumor necrosis factor-alpha (TNF-alpha) , leading to increased intracellular calcium response to agonists ... In HASM cells,
TNF-alpha augmented
CD38 expression and ADP-ribosyl cyclase activity, which were attenuated by dexamethasone ... An inhibitor of NF-kappaB activation or transfection of cells with IkappaB mutants decreased
TNF-alpha induced
CD38 expression ... The results indicate that
TNF-alpha induced
CD38 expression involves NF-kappaB expression and its activation and dexamethasone inhibits CD38 expression through NF-kappaB dependent and -independent mechanisms
Iqbal et al., American journal of physiology. Renal physiology 2006
:
TNF but not RANK-L
led to the sustained upregulation of both
CD38 and CD157 as demonstrated by real-time PCR and flow cytometry
Iqbal et al., American journal of physiology. Renal physiology 2007
:
We show that
TNF-alpha induced
CD38 expression negatively affects the expression of osteoclast markers, while it enhances inflammatory gene expression by decreasing ERK1/2 phosphorylation and increasing NF-kappaB activation
Kang et al., Br J Nutr 2007
:
In the present study, we examined the
effects of
t10c12-CLA on PPARgamma and
TNF-alpha expression of porcine PBMC and the phagocytic capacity of PMN ...
t10c12-CLA increased
TNF-alpha mRNA expression and production by PBMC
Tirumurugaan et al., Am J Physiol Lung Cell Mol Physiol 2007
(MAP Kinase Signaling System) :
TNF-alpha induced
CD38 expression in human airway smooth muscle cells : role of MAP kinases and transcription factors NF-kappaB and AP-1 ... In human airway smooth muscle ( HASM ) cells, the expression of
CD38 , which synthesizes the calcium mobilizing molecule cyclic ADP-ribose, is
augmented by
TNF-alpha , a cytokine implicated in asthma ... Transfection of HASM cells with a dominant negative MEK decreased while a wild-type ERK increased
TNF-alpha induced
CD38 expression ... Transfection of a dominant negative c-Jun decreased
TNF-alpha induced
CD38 expression indicating involvement of AP-1 ... Stability of
TNF-alpha induced
CD38 transcripts were determined in the presence of MAPK inhibitors after arresting the transcription with actinomycin D. Transcript stability decreased in the presence of ERK and p38 MAPK, but not the JNK, inhibitors
Guedes et al., Am J Physiol Lung Cell Mol Physiol 2008
(Bronchial Hyperreactivity...) :
CD38 is involved in normal airway function, IL-13 induced airway hyperresponsiveness (AHR), and is also
regulated by
tumor necrosis factor (TNF)-alpha in airway smooth muscle ( ASM ) cells ... This study aimed to determine whether
TNF-alpha induced
CD38 upregulation in ASM cells contributes to AHR, a hallmark of asthma
Sieck et al., Am J Physiol Lung Cell Mol Physiol 2008
(Calcium Signaling) :
In the present study, we tested the hypothesis that the
effects of
TNFalpha on
CD38 expression vs. changes in [ Ca ( 2+ ) ] ( i ) regulation in ASM cells are linked ... Results confirmed that
TNFalpha significantly
increased CD38 expression and ADP-ribosyl cyclase activity, an effect inhibited by CD38 siRNA, but unaltered by CD38 overexpression
Cho et al., Res Vet Sci 2008
:
t10c12-CLA also
increased TNF-alpha production by PBMC
Tirumurugaan et al., Respir Res 2008
(Bronchial Hyperreactivity) :
CD38 is expressed in human airway smooth muscle ( HASM ) cells, regulates intracellular calcium, and its expression is
augmented by
tumor necrosis factor alpha (TNF-alpha)
Kang et al., Am J Physiol Lung Cell Mol Physiol 2008
(MAP Kinase Signaling System) :
Dexamethasone also decreased
CD38 expression
induced by
TNF-alpha , and part of this effect was attributable to decreased transcript stability
Sigl et al., Acta Vet Scand 2010
:
Furthermore the experiment did not indicate significant
effects of c9,t11- and
t10 , c12-CLA-supplementation on gene expression of peroxisome proliferator activated receptor-alpha ( PPARalpha ), PPARgamma, sterol regulatory element binding protein-1 and
tumor necrosis factor-alpha in liver tissue
Kim et al., Br J Nutr 2011
:
The aim of the present study was to assess the
effect of
t10c12-CLA on PPAR? activation, NF-?B activation and
TNF-a expression in lipopolysaccharide (LPS)-naive and LPS stimulated porcine peripheral blood mononuclear cells ( PBMC ) ... GW9662, a PPAR? antagonist, completely negated the modulating
effects of
t10c12-CLA on
TNF-a expression and NF-?B activity in both LPS-naive and LPS stimulated porcine PBMC
Jude et al., Am J Respir Cell Mol Biol 2012
(Asthma) :
In human airway smooth muscle ( HASM ) cells,
TNF-a mediates
CD38 expression through mitogen activated protein kinases and NF-?B and AP-1 ... We hypothesized that PI3Ks mediate CD38 expression and are involved in the differential
induction of
CD38 by
TNF-a in asthmatic HASM cells ... P110 expression caused Akt activation and basal and
TNF-a induced
CD38 expression, whereas PTEN expression attenuated Akt activation and CD38 expression ... Silencing of p110a or -d, but not p110ß, resulted in comparable attenuation of
TNF-a induced
CD38 expression in asthmatic and nonasthmatic cells
Jude et al., Am J Physiol Lung Cell Mol Physiol 2012
(Asthma...) :
miR-140-3p regulation of
TNF-a induced
CD38 expression in human airway smooth muscle cells ... In human ASM ( HASM ) cells,
TNF-a induces
CD38 expression through activation of MAPKs, NF-?B, and AP-1, and its expression is differentially elevated in cells from asthmatic patients compared with cells from nonasthmatic subjects