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CD28 — CD3D

Pathways - manually collected, often from reviews:

• NCI Pathway Database TCR signaling in naïve CD8+ T cells: TCR/CD3/MHC I/CD8 complex (CD247-CD3E-CD3G-CD3D-HLA-A-B2M-CD8A-CD8B) → B7 family/CD28 complex (CD28-CD80_CD86) (modification, collaborate)
  Housden et al., Eur J Biochem 2003, Barber et al., Proc Natl Acad Sci U S A 1989, van Oers et al., J Exp Med 1996, Anel et al., Eur J Immunol 1996
  Evidence: mutant phenotype, assay, physical interaction, other species
• NCI Pathway Database TCR signaling in naïve CD8+ T cells: B7 family/CD28 complex (CD28-CD80_CD86) → TCR/CD3/MHC I/CD8/LCK complex (CD247-CD3E-CD3G-CD3D-HLA-A-B2M-CD8A-CD8B-LCK) (modification, activates)
  Housden et al., Eur J Biochem 2003, Barber et al., Proc Natl Acad Sci U S A 1989, van Oers et al., J Exp Med 1996, Anel et al., Eur J Immunol 1996
  Evidence: mutant phenotype, assay, physical interaction, other species
• NCI Pathway Database TCR signaling in naïve CD4+ T cells: TCR/CD3/MHC II/CD4/LCK complex (CD3E-CD3G-CD3D-HLA-DRA-HLA-DRB1-CD4-LCK-CD247) → B7 family/CD28 complex (CD28-CD80_CD86) (modification, collaborate)
  Pelosi et al., J Biol Chem 1999, Iwashima et al., Science 1994, Chan et al., J Immunol 1994, van Oers et al., J Exp Med 1996, Tuosto et al., Eur J Immunol 1998
  Evidence: mutant phenotype, assay
• NCI Pathway Database TCR signaling in naïve CD4+ T cells: B7 family/CD28 complex (CD28-CD80_CD86) → TCR/CD3/MHC II/CD4/LCK/ZAP-70 complex (CD247-CD3E-CD3G-CD3D-HLA-DRA-HLA-DRB1-CD4-LCK-ZAP70) (modification, activates)
  Pelosi et al., J Biol Chem 1999, Iwashima et al., Science 1994, Chan et al., J Immunol 1994, van Oers et al., J Exp Med 1996, Tuosto et al., Eur J Immunol 1998
  Evidence: mutant phenotype, assay
• NCI Pathway Database TCR signaling in naïve CD8+ T cells: TCR/CD3/MHC I/CD8 complex (CD247-CD3E-CD3G-CD3D-HLA-A-B2M-CD8A-CD8B) → B7 family/CD28 complex (CD28-CD80_CD86) (transcription, activates)
  Curtsinger et al., J Exp Med 2003
  Evidence: assay, other species
• NCI Pathway Database TCR signaling in naïve CD4+ T cells: TCR/CD3/MHC II/CD4/LCK complex (CD3E-CD3G-CD3D-HLA-DRA-HLA-DRB1-CD4-LCK-CD247) → B7 family/CD28 complex (CD28-CD80_CD86) (modification, activates)
  Woods et al., EMBO J 2001, Wilcox et al., J Biol Chem 2003, August et al., Proc Natl Acad Sci U S A 1994, Raab et al., Proc Natl Acad Sci U S A 1995, Gibson et al., J Biol Chem 1996, Heyeck et al., J Biol Chem 1997
  Evidence: mutant phenotype, assay, physical interaction
• NCI Pathway Database TCR signaling in naïve CD4+ T cells: B7 family/CD28 complex (CD28-CD80_CD86) → TCR/CD3/MHC II/CD4 complex (CD247-CD3E-CD3G-CD3D-HLA-DRA-HLA-DRB1-CD4) (modification, activates)
  Housden et al., Eur J Biochem 2003, Barber et al., Proc Natl Acad Sci U S A 1989, van Oers et al., J Exp Med 1996, Kersh et al., Science 1998, Tuosto et al., Eur J Immunol 1998, Viola et al., Science 1999
  Evidence: mutant phenotype, assay
• NCI Pathway Database TCR signaling in naïve CD8+ T cells: B7 family/CD28 complex (CD28-CD80_CD86) → TCR/CD3/MHC I/CD8/LCK complex (CD247-CD3E-CD3G-CD3D-HLA-A-B2M-CD8A-CD8B-LCK) (modification, activates)
  Iwashima et al., Science 1994
  Evidence: assay, physical interaction
• NCI Pathway Database TCR signaling in naïve CD4+ T cells: TCR/CD3/MHC II/CD4/LCK complex (CD3E-CD3G-CD3D-HLA-DRA-HLA-DRB1-CD4-LCK-CD247) → B7 family/CD28 complex (CD28-CD80_CD86) (modification, activates)
  Raab et al., Proc Natl Acad Sci U S A 1995
  Evidence: mutant phenotype, assay

Text-mined interactions from Literome

Grader-Beck et al., Blood 2003 : Here, using primary human T lymphocytes in which endogenous cAMP was increased by the use of forskolin and 3-isobutyl-1-methylxanthine ( IBMX ), we show that increase of cAMP resulted in inhibition of T-cell receptor (TCR)/CD3 plus CD28 mediated T-cell activation and cytokine production and blockade of cell cycle progression at the G ( 1 ) phase
Matsumoto et al., Microbiol Immunol 2003 : For T cell activation, two signals are required, i.e., a T cell receptor (TCR)/CD3 mediated main signal and a CD28 mediated costimulatory signal
Verwilghen et al., J Immunol 1993 : CD5/CD28 ligation induced production of TNF-alpha, but not of IL-4, and did not induce modulation of the TCR/CD3 complex