Gene interactions and pathways from curated databases and text-mining

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CD3E — LCK

Pathways - manually collected, often from reviews:

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

Text-mined interactions from Literome

Doucey et al., Eur J Immunol 2001 : Additional cross linking further increases p56lck kinase activity, induces translocation of TCR/CD3 and other signaling molecules to lipid rafts and intracellular calcium mobilization
Danielian et al., Eur J Immunol 1992 : Both T cell receptor (TcR)-CD3 complex and CD2 increase the tyrosine kinase activity of p56lck ... Therefore, to test directly the role of TcR-CD3 in CD2 induced activation of p56lck , we utilized mutant variants of the Jurkat cell line lacking in cell surface TcR-CD3 ... We found that cell surface expression of TcR-CD3 is not required for the activation of p56lck via CD2 but is necessary for the appearance of the reduced-electrophoretic-mobility form of p56lck observed after CD2 triggering
Thome et al., J Exp Med 1995 : Evidence has suggested that the association of CD4 with TCR/CD3/zeta requires the interaction of the protein tyrosine kinase p56lck with CD4
Wang et al., J Immunol 1995 (Lymphoma, B-Cell) : In vitro kinase assay studies also demonstrated that TCR-CD3 engagement increased the kinase activity of Lck in normal T cells but not in T-TIL