Gene interactions and pathways from curated databases and text-mining

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CD4 — PIK3R1

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

Text-mined interactions from Literome

Phu et al., J Leukoc Biol 2001 : PI3-K inhibition resulted in a modest decrease in anti-CD3 induced CD4 ( + ) T-cell proliferation but failed to affect IL-2 expression by anti-CD3 activated CD4 ( + ) T cells
Trucy et al., Cell Immunol 2006 : CD4 binding also increases interactions between PI3K and activated PKCzeta and PDK1
Gamper et al., Frontiers in immunology 2012 : In this review, we focus on how PI3K activation directs mature CD4 T cell activation and effector function by pathways dependent on and independent of mTOR signaling