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CD44 — ERBB2

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

• IRef Biogrid Interaction: CD44 — ERBB2 (physical association, affinity chromatography technology) Tsatas et al., J Clin Neurosci 2002*
• IRef Hprd Interaction: Complex of 26 proteins (in vivo) Bourguignon et al., J Biol Chem 2007*
• IRef Intact Interaction: Complex of WASL-ERBB2-CD44 (association, anti bait coimmunoprecipitation) Bourguignon et al., J Biol Chem 2007*

Text-mined interactions from Literome

Ghatak et al., J Biol Chem 2005 (Breast Neoplasms...) : In this study we show that constitutively high levels of active, i.e. autophosphorylated, ErbB2 in HCT116 colon carcinoma cells and TA3/St mammary carcinoma cells are dependent on endogenous hyaluronan-CD44 interaction
Bourguignon et al., J Biol Chem 2007 (Ovarian Neoplasms) : Hyaluronan-CD44 interaction with neural Wiskott-Aldrich syndrome protein ( N-WASP ) promotes actin polymerization and ErbB2 activation leading to beta-catenin nuclear translocation, transcriptional up-regulation, and cell migration in ovarian tumor cells